Continuous neomycin production by immobilized cells of Streptomyces marinensis NUV-5 in an airlift bioreactor

被引：12

作者：

Adinarayana, K ^{[1
]}

Srinivasulu, B ^{[1
]}

Raju, KVVSNB ^{[1
]}

Ellaiah, P ^{[1
]}

机构：

[1] Andhra Univ, Dept Pharmaceut Sci, Pharmaceut Biotechnol Div, Visakhapatnam 530003, Andhra Pradesh, India

来源：

PROCESS BIOCHEMISTRY | 2004年 / 39卷 / 11期

关键词：

neomycin; Streptomyces marinensis NUV-5; continuous fermentation; airlift reactor;

D O I：

10.1016/S0032-9592(03)00271-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neomycin production by free and calcium alginate immobilized cells was investigated in an airlift reactor. The average volumetric productivity with continuous fermentation (72.97 mg/l/h) was greater than with free cells (45.05 mg/l/h). The total neomycin produced with continuous fermentation was 62% greater than with that of free cells. Immobilized Streptomyces particles showed a half-life of 42 days during continuous fermentation under airlift conditions. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1407 / 1414

页数：8

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