Taxol inhibits opioid binding on T47D human breast cancer cells

被引:7
作者
Bakogeorgou, E
Hatzoglou, A
Castanas, E
机构
[1] UNIV CRETE,SCH MED,LAB EXPT ENDOCRINOL,GR-71110 IRAKLION,GREECE
[2] UNIV HOSP HERAKLION,GR-71110 IRAKLION,GREECE
[3] INSERM,CJF 9311,F-13916 MARSEILLE,FRANCE
[4] INSERM,CJF 9502,F-92140 CLAMART,FRANCE
关键词
D O I
10.1006/bbrc.1997.6688
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the T47D human breast cancer cell line, Taxol was found to compete for ethylketocyclazocine opioid binding (IC50 3.3 pM). In contrast, no interaction of the drug with [H-3]diprenorphine binding occurred. Binding was multiphasic, in the absence of colchicine (10(-6) M), but monophasic in its presence, indicating an involvement of the cytoskeleton in this process. Alignment of Taxol binding domains on alpha and beta tubulin with the kappa opioid site revealed homology of these sites with the first extracellular loop of the receptor. These results indicate a possible new action of Taxol, indicating for the first time a membrane action of the agent. (C) 1997 Academic Press.
引用
收藏
页码:201 / 204
页数:4
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