Evaluating the impact of cannabis use on thalamic connectivity in youth at clinical high risk of psychosis

被引：15

作者：

Buchy, Lisa ^{[1
]}

Cannon, Tyrone D. ^{[2
]}

Anticevic, Alan ^{[3
]}

Lyngberg, Kristina ^{[4
]}

Cadenhead, Kristin S. ^{[5
]}

Cornblatt, Barbara A. ^{[6
]}

McGlashan, Thomas H. ^{[3
]}

Perkins, Diana O. ^{[7
]}

Seidman, Larry J. ^{[8
,9
]}

Tsuang, Ming T. ^{[6
]}

Walker, Elaine F. ^{[10
,11
]}

Woods, Scott W. ^{[3
]}

Bearden, Carrie E. ^{[12
,13
]}

Mathalon, Daniel H. ^{[14
]}

Addington, Jean ^{[1
,15
]}

机构：

[1] Univ Calgary, Dept Psychiat, Calgary, AB, Canada

[2] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[4] Univ Calgary, Fac Sci, Dept Neurosci, Calgary, AB, Canada

[5] UCSD, Dept Psychiat, La Jolla, CA USA

[6] Zucker Hillside Hosp, Dept Psychiat, Long Isl City, NY USA

[7] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[8] Harvard Univ, Sch Med, Dept Psychiat, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[9] Massachusetts Gen Hosp, Boston, MA 02114 USA

[10] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[11] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA

[12] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[13] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA

[14] Univ Calif San Francisco, San Francisco, CA 94143 USA

[15] Univ Calgary, Mathison Ctr Mental Hlth Res & Educ, Calgary, AB T2N 4Z6, Canada

来源：

BMC PSYCHIATRY | 2015年 / 15卷

关键词：

Cannabis; Clinical high risk; Functional connectivity; Resting state functional magnetic resonance imaging; Psychosis; Schizophrenia; Thalamus; BRAIN STRUCTURAL ALTERATIONS; SUBSTANCE USE; 1ST-EPISODE SCHIZOPHRENIA; ADULT PSYCHOSIS; CB1; RECEPTOR; INDIVIDUALS; VOLUME; DYSCONNECTIVITY; DEFICITS; PEOPLE;

D O I：

10.1186/s12888-015-0656-x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Disruptions in thalamic functional connectivity have been observed in people with schizophrenia and in youth at clinical high risk (CHR) of psychosis. However, the impact of environmental risk factors for psychosis on thalamic dysconnectivity is poorly understood. We tested whether thalamic dysconnectivity is related to patterns of cannabis use in a CHR sample. Methods: 162 CHR and 105 control participants were assessed on cannabis use severity, frequency, and age at onset of first use as part of the North American Prodrome Longitudinal Study and completed resting-state fMRI scans. Whole-brain thalamic functional connectivity maps were generated using individual subjects' anatomically defined thalamic seeds. Results: Thalamic connectivity did not significantly correlate with current cannabis use severity or frequency in either CHR or controls. In CHR cannabis users, a significant correlation emerged between attenuated thalamic connectivity with left sensory/motor cortex and a younger age at onset of cannabis use. CHR who used cannabis before age 15 did not differ on thalamic connectivity as compared to CHR who used after age 15 or CHR who were cannabis naive. No group differences in thalamic connectivity emerged when comparing CHR separated by moderate/high use frequency, low-frequency or cannabis naive. Conclusions: Although a younger age at onset of cannabis use may be associated with disrupted thalamo-cortical coupling, cannabis use does not appear to be an identifying characteristic for thalamic connectivity in CHR with moderate/high use frequency compared to low-frequency users or CHR who are cannabis naive.

引用

页数：9