microRNA regulation of lipoprotein metabolism

被引：33
作者：
Goedeke, Leigh [1 ,2 ,3 ]
Aranda, Juan F. [1 ,2 ]
Fernandez-Hernando, Carlos [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Vasc Biol & Therapeut Program, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Integrat Cell Signaling & Neurobiol Metab Program, Comparat Med Sect, New Haven, CT 06510 USA
[3] NYU, Sch Med, Dept Med, Leon H Charney Div Cardiol, New York, NY USA
来源：
CURRENT OPINION IN LIPIDOLOGY | 2014年 / 25卷 / 04期
基金：
美国国家卫生研究院;
关键词：
cholesterol homeostasis; lipoprotein metabolism; miRNAs; HIGH-DENSITY-LIPOPROTEIN; CASSETTE TRANSPORTER A1; CHOLESTEROL HOMEOSTASIS; LIPID-METABOLISM; TANGIER-DISEASE; IN-VIVO; NONHUMAN-PRIMATES; BINDING; EXPRESSION; RECEPTOR;
D O I：
10.1097/MOL.0000000000000094
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Purpose of review The objective of this review article is to summarize the recent findings about the importance of microRNAs (miRNAs) in regulating lipoprotein metabolism. We highlight the recent findings that uncover the importance of miRNAs in controlling plasma LDL-cholesterol (LDL-C) levels. Recent findings In 2013, several studies reported a number of miRNAs that regulate plasma LDL-C levels, including miR-30c. In this review article, we discuss those miRNAs that modulate LDL-C levels and lipoprotein secretion. We also discuss the numerous studies that demonstrate the critical role of miRNAs in governing the many facets of HDL metabolism, such as the ATP transporters, ABCA1, and ABCG1, and the scavenger receptor, SRB1. Summary The understanding of how these miRNAs modulate lipoprotein metabolism promises to reveal new therapeutic targets to treat dyslipidemias and related cardiovascular disorders.
引用
收藏
页码：282 / 288
页数：7
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