Synthesis of 3-alkylideneisoindolinones and isoindolones by a Horner-Wadsworth-Emmons reaction

被引：16
作者：
Angel Reyes-Gonzalez, Miguel [1 ]
Zamudio-Medina, Angel [1 ]
Abelardo Ramirez-Marroquin, Oscar [1 ]
Ordonez, Mario [1 ]
机构：
[1] Univ Autonoma Estado Morelos, Ctr Invest Quim, Cuernavaca, Morelos, Mexico
来源：
MONATSHEFTE FUR CHEMIE | 2014年 / 145卷 / 06期
关键词：
Phosphonates; Three-component reaction; Wittig reaction; Heterocycles; ISOINDOLINONE DERIVATIVES; STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; INHIBITORY-ACTIVITY; POTENT INHIBITORS; CYCLIZATION; NITROGEN; ANALOG; LENNOXAMINE; DISCOVERY;
D O I：
10.1007/s00706-013-1146-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 3-alkylideneisoindolinones was prepared by a Horner-Wadsworth-Emmons (HWE) reaction of aromatic aldehydes with N-(omega-hydroxyalkyl)substituted 3-phosphoisoindolin-1-ones, obtained in one-pot synthesis from 2-formylbenzoic acid. Additionally, the intramolecular HWE reaction of the N-(omega-formylalkyl)substituted phosphoisoindolin-1-ones afforded the corresponding isoindolone derivatives.
引用
收藏
页码：1001 / 1007
页数：7
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