Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis

被引:13
作者
Wickramasinghe, A. [1 ]
Tulloch, A. D. [1 ]
Hayes, R. D. [1 ]
Chang, C-K [1 ]
Broadbent, M. [2 ]
Di Forti, M. [1 ]
Murray, R. M. [1 ]
Iyegbe, C. [1 ]
Stewart, R. [1 ]
机构
[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England
[2] South London & Maudsley NHS Fdn Trust, London, England
来源
TRANSLATIONAL PSYCHIATRY | 2015年 / 5卷
基金
英国医学研究理事会;
关键词
RISK VARIANT; BIPOLAR DISORDER; HUMAN BRAIN; PREDICTORS; EXPRESSION; RS1344706; SYMPTOMS; CANNABIS; REGIONS; LENGTH;
D O I
10.1038/tp.2015.198
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record case register at the South London and Maudsley NHS Foundation Trust-a large provider of secondary mental-health care. A sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20-29 or F30-33) and in whom the rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode occurred and the number of in-patient episodes during this period. A strong association was found between the number of rs1344706 A alleles and the cumulative duration of mental-health in-patient stay over the 2 years since initial presentation. In the 84.2% who experienced an in-patient episode during this period, the mean duration of admission was an additional 38 days for each A allele increment. Therefore, in addition to its potential role as a risk factor for psychosis, the ZNF804A rs1344706 A allele is associated with worse clinical outcome.
引用
收藏
页码:e698 / e698
页数:5
相关论文
共 36 条
[1]   Effects of cis-regulatory variation differ across regions of the adult human brain [J].
Buonocore, Federica ;
Hill, Matthew J. ;
Campbell, Colin D. ;
Oladimeji, Paul B. ;
Jeffries, Aaron R. ;
Troakes, Claire ;
Hortobagyi, Tibor ;
Williams, Brenda P. ;
Cooper, Jonathan D. ;
Bray, Nicholas J. .
HUMAN MOLECULAR GENETICS, 2010, 19 (22) :4490-4496
[2]   Hospitalisation as an outcome measure in schizophrenia [J].
Burns, Tom .
BRITISH JOURNAL OF PSYCHIATRY, 2007, 191 :S37-S41
[3]   Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137 [J].
Cummings, E. ;
Donohoe, G. ;
Hargreaves, A. ;
Moore, S. ;
Fahey, C. ;
Dinan, T. G. ;
McDonald, C. ;
O'Callaghan, E. ;
O'Neill, F. A. ;
Waddington, J. L. ;
Murphy, K. C. ;
Morris, D. W. ;
Gill, M. ;
Corvin, A. .
NEUROSCIENCE LETTERS, 2013, 532 :33-38
[4]   Predictors of length of hospital stay [J].
Daradkeh, TK ;
ElRufaie, OEF ;
Reda, F ;
Karim, L .
NORDIC JOURNAL OF PSYCHIATRY, 1996, 50 (02) :127-131
[5]   The varied outcomes of schizophrenia [J].
Davidson, L ;
McGlashan, TH .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 1997, 42 (01) :34-43
[6]   Confirmation that the AKT1 (rs2494732) Genotype Influences the Risk of Psychosis in Cannabis Users [J].
Di Forti, Marta ;
Iyegbe, Conrad ;
Sallis, Hannah ;
Kolliakou, Anna ;
Falcone, M. Aurora ;
Paparelli, Alessandra ;
Sirianni, Miriam ;
La Cascia, Caterina ;
Stilo, Simona A. ;
Marques, Tiago Reis ;
Handley, Rowena ;
Mondelli, Valeria ;
Dazzan, Paola ;
Pariante, Carmine ;
David, Anthony S. ;
Morgan, Craig ;
Powell, John ;
Murray, Robin M. .
BIOLOGICAL PSYCHIATRY, 2012, 72 (10) :811-816
[7]   High-potency cannabis and the risk of psychosis [J].
Di Forti, Marta ;
Morgan, Craig ;
Dazzan, Paola ;
Pariante, Carmine ;
Mondelli, Valeria ;
Marques, Tiago Reis ;
Handley, Rowena ;
Luzi, Sonija ;
Russo, Manuela ;
Paparelli, Alessandra ;
Butt, Alexander ;
Stilo, Simona A. ;
Wiffen, Ben ;
Powell, John ;
Murray, Robin M. .
BRITISH JOURNAL OF PSYCHIATRY, 2009, 195 (06) :488-491
[8]   Neural Mechanisms of a Genome-Wide Supported Psychosis Variant [J].
Esslinger, Christine ;
Walter, Henrik ;
Kirsch, Peter ;
Erk, Susanne ;
Schnell, Knut ;
Arnold, Claudia ;
Haddad, Leila ;
Mier, Daniela ;
von Boberfeld, Carola Opitz ;
Raab, Kyeon ;
Witt, Stephanie H. ;
Rietschel, Marcella ;
Cichon, Sven ;
Meyer-Lindenberg, Andreas .
SCIENCE, 2009, 324 (5927) :605-605
[9]   Neurocognition and community outcome in schizophrenia: long-term predictive validity [J].
Fujii, DE ;
Wylie, AM .
SCHIZOPHRENIA RESEARCH, 2003, 59 (2-3) :219-223
[10]   How Might ZNF804A Variants Influence Risk for Schizophrenia and Bipolar Disorder? A Literature Review, Synthesis, and Bioinformatic Analysis [J].
Hess, Jonathan L. ;
Glatt, Stephen J. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2014, 165 (01) :28-40