Significance of preoperative fluorodeoxyglucose-positron emission tomography in prediction of tumor recurrence after liver transplantation for hepatocellular carcinoma patients: a Japanese multicenter study

被引：38

作者：

Takada, Yasutsugu ^{[1
]}

Kaido, Toshimi ^{[2
]}

Shirabe, Ken ^{[3
]}

Nagano, Hiroaki ^{[4
]}

Egawa, Hiroto ^{[5
]}

Sugawara, Yasuhiko ^{[6
]}

Taketomi, Akinobu ^{[7
]}

Takahara, Takeshi ^{[8
]}

Wakabayashi, Go ^{[9
]}

Nakanishi, Chikashi

Kawagishi, Naoki ^{[10
]}

Kenjo, Akira ^{[11
]}

Gotoh, Mitsukazu ^{[11
]}

Toyoki, Yoshikazu ^{[12
]}

Hakamada, Kenichi ^{[12
]}

Ohtsuka, Masayuki ^{[13
]}

Akamatsu, Nobuhisa ^{[14
]}

Kokudo, Norihiro ^{[14
]}

Takeda, Kazuhisa ^{[15
]}

Endo, Itaru ^{[16
]}

Takamura, Hiroyuki ^{[17
]}

Okajima, Hideaki ^{[2
]}

Wada, Hiroshi ^{[18
]}

Kubo, Shoji ^{[19
]}

Kuramitsu, Kaoru ^{[20
]}

Ku, Yonson ^{[20
]}

Ishiyama, Kohei ^{[21
]}

Ohdan, Hideki ^{[21
]}

Ito, Eitaro ^{[1
]}

Maehara, Yoshihiko ^{[22
]}

Honda, Masaki ^{[6
]}

Inomata, Yukihiro ^{[6
]}

Furukawa, Hiroyuki ^{[23
]}

Uemoto, Shinji ^{[2
]}

Yamaue, Hiroki ^{[24
]}

Miyazaki, Masaru ^{[25
]}

Takada, Tadahiro ^{[26
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept HBP & Breast Surg, Toon, Ehime 7910295, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Surg, Div HBP Surg & Transplantat, Kyoto, Japan

[3] Gunma Univ, Dept Hepatobiliary & Pancreat Surg, Gunma, Japan

[4] Iwate Med Univ, Sch Med, Dept Surg, Morioka, Iwate, Japan

[5] Tokyo Womens Med Univ, Dept Surg, Tokyo, Japan

[6] Kumamoto Univ, Postgrad Sch Life Sci, Dept Transplantat & Pediat Surg, Kumamoto, Japan

[7] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol Surg 1, Sapporo, Hokkaido, Japan

[8] Iwate Med Univ, Sch Med, Dept Surg, Morioka, Iwate, Japan

[9] Ageo Cent Gen Hosp, Surg Serv, Ctr Adv Treatment Hepatobiliary & Pancreat Dis, Saitama, Japan

[10] Tohoku Univ Hosp, Dept Transplantat Reconstruct & Endoscop Surg, Sendai, Miyagi, Japan

[11] Fukushima Med Univ, Dept Regenerat Surg, Fukushima, Japan

[12] Hirosaki Univ, Grad Sch Med, Dept Surg Gastroenterol, Aomori, Japan

[13] Chiba Univ, Grad Sch Med, Dept Gen Surg, Chiba, Japan

[14] Univ Tokyo, Dept Surg, Artificial Organ & Transplantat Surg Div, Tokyo, Japan

[15] Natl Hosp Org, Yokohama Med Ctr, Kanagawa, Japan

[16] Yokohama City Univ, Grad Sch Med, Dept Surg Gastroenterol, Kanagawa, Japan

[17] Kanazawa Univ, Dept Surg Gastroenterol, Kanazawa, Ishikawa, Japan

[18] Osaka Univ, Grad Sch Med, Dept Surg Gastroenterol, Osaka, Japan

[19] Osaka City Univ, Grad Sch Med, Dept Hepatobiliary Pancreat Surg, Osaka, Japan

[20] Kobe Univ Hosp, Hepatobiliary Pancreat Surg, Kobe, Hyogo, Japan

[21] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Gastroenterol & Transplant Surg, Appl Life Sci, Hiroshima, Japan

[22] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka, Japan

[23] Asahikawa Med Univ, Dept Surg, Div Gastroenterol Surg, Asahikawa, Hokkaido, Japan

[24] Wakayama Med Univ, Sch Med, Dept Surg 2, Wakayama, Japan

[25] Int Univ Hlth & Welf, Mita Hosp, Tokyo, Japan

[26] Teikyo Univ, Sch Med, Japanese Soc Hepatobiliary Pancreat Surg, Dept Surg, Tokyo, Japan

来源：

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES | 2017年 / 24卷 / 01期

关键词：

Biological marker; Hepatocellular carcinoma; Liver transplantation; Selection criteria; GAMMA-CARBOXY PROTHROMBIN; SELECTION CRITERIA; MILAN CRITERIA; EXPERIENCE; EXPANSION; FLUORINE-18-FLUORODEOXYGLUCOSE; RECIPIENTS; RESECTION; SURVIVAL; INVASION;

D O I：

10.1002/jhbp.412

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background In the present study, we conducted a multicenter nationwide survey to investigate the effects of preoperative fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the prediction of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). Methods From 16 Japanese LT centers, data were collected on 182 recipients with HCC who underwent living donor liver transplantation (LDLT) between February 2005 and November 2013. PET-positive status was defined as increased uptake of FDG in the tumor compared to the surrounding non-tumor liver tissue. The median follow-up after LDLT was 54.5 months (range 1-125 months). Results Postoperative HCC recurrence occurred in 23 patients. Multivariate analysis revealed that exceeding the Milan criteria (MC), alpha-fetoprotein (AFP) level >= 115 ng/ml, and PET-positive status were significant and independent risk factors for recurrence. In the over-MC group, a subgroup of patients with AFP level < 115 ng/ml and PET-negative status (n = 22) had a significantly lower 5-year recurrence rate than the other patients (n = 27, 19% vs. 53%, P = 0.019). Conclusions These results suggest that preoperative FDG-PET status offers additional information on HCC recurrence risk after LT. Over-MC patients with PET-negative status and lower AFP level may achieve successful outcome comparable to that of within-MC patients.

引用

页码：49 / 57

页数：9

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