Synthesis of a novel dimeric bis-benzimidazole with site-selective DNA-binding properties

被引:15
作者
Sun, XW
Neidle, S
Mann, J
机构
[1] Queens Univ Belfast, Sch Chem, Belfast BT9 5AG, Antrim, North Ireland
[2] Inst Canc Res, Biomol Struct Unit, London SW3 6JB, England
关键词
D O I
10.1016/S0040-4039(02)01595-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We describe the synthesis of bis(3-{4-[2'-(4-methoxyphenyl)-3H,3'H-[5,5']bibenzimidazolyl-2-yl]phenoxy} propyl)-methylamine 8, which has high affinity for the oligonucleotide sequence [A.T](4)-[G.C]-[A.T](4). (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码:7239 / 7241
页数:3
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