Synthesis of a novel dimeric bis-benzimidazole with site-selective DNA-binding properties

被引：15
作者：
Sun, XW
Neidle, S
Mann, J
机构：
[1] Queens Univ Belfast, Sch Chem, Belfast BT9 5AG, Antrim, North Ireland
[2] Inst Canc Res, Biomol Struct Unit, London SW3 6JB, England
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 40期
关键词：
D O I：
10.1016/S0040-4039(02)01595-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe the synthesis of bis(3-{4-[2'-(4-methoxyphenyl)-3H,3'H-[5,5']bibenzimidazolyl-2-yl]phenoxy} propyl)-methylamine 8, which has high affinity for the oligonucleotide sequence [A.T](4)-[G.C]-[A.T](4). (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码：7239 / 7241
页数：3
相关论文
共 50 条
  • [41] SYNTHESIS AND DNA-BINDING PROPERTIES OF A PURINE ANALOG OF BISBENZIMIDE
    LEE, M
    SPOTTS, PH
    ECKERT, J
    WALKER, C
    NOBLES, JA
    HETEROCYCLES, 1991, 32 (11) : 2093 - 2097
  • [42] (-)-SANDRAMYCIN - TOTAL SYNTHESIS AND PRELIMINARY DNA-BINDING PROPERTIES
    BOGER, DL
    CHEN, JH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 209 : 345 - ORGN
  • [43] Antiproliferative activity of bicyclic benzimidazole nucleosides: synthesis, DNA-binding and cell cycle analysis
    Sontakke, Vyankat A.
    Lawande, Pravin P.
    Kate, Anup N.
    Khan, Ayesha
    Joshi, Rakesh
    Kumbhar, Anupa A.
    Shinde, Vaishali S.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 14 (17) : 4136 - 4145
  • [44] Novel DNA-binding properties of the RNA-binding protein TIAR
    Suswam, EA
    Li, YY
    Mahtani, H
    King, PH
    NUCLEIC ACIDS RESEARCH, 2005, 33 (14) : 4507 - 4518
  • [45] DNA-Binding Properties of Bis-N-substituted Tetrandrine Derivatives
    Monica Gonzalez-Martinez, Sandra
    Pettry Valencia-Ochoa, Drochss
    Carlos Galvez-Ruiz, Juan
    Alberto Leyva-Peralta, Mario
    Juarez-Sanchez, Octavio
    Islas-Osuna, Maria A.
    Isabel Calvillo-Paez, Viviana
    Hopfl, Herbert
    Iniguez-Palomares, Ramon
    Rocha-Alonzo, Fernando
    Ochoa Lara, Karen
    ACS OMEGA, 2022, 7 (19): : 16380 - 16390
  • [46] Templated Synthesis and Site-Selective Conversion of Completely Nonsymmetrical Bis-Metallosalphen Complexes
    Castilla, Ana M.
    Curreli, Simona
    Carretero, Nina M.
    Escudero-Adan, Eduardo C.
    Benet-Buchholz, Jordi
    Kleij, Arjan W.
    EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2009, (17) : 2467 - 2471
  • [47] 3,4-Dimethoxyphenyl bis-benzimidazole, a novel DNA topoisomerase inhibitor that preferentially targets Escherichia coli topoisomerase I
    Bansal, Sandhya
    Sinha, Devapriya
    Singh, Manish
    Cheng, Bokun
    Tse-Dinh, Yuk-Ching
    Tandon, Vibha
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (12) : 2882 - 2891
  • [48] Novel DNA-binding protein from Drosophila embryos identified by binding site selection
    Todorovic, V
    Kojic, S
    Vujanac, M
    Savic, A
    Stefanovic, D
    FEBS LETTERS, 1996, 396 (01) : 99 - 102
  • [49] SITE-SELECTIVE BIS-INTERCALATION OF A HOMODIMERIC THIAZOLE ORANGE-DYE IN DNA OLIGONUCLEOTIDES
    JACOBSEN, JP
    PEDERSEN, JB
    HANSEN, LF
    WEMMER, DE
    NUCLEIC ACIDS RESEARCH, 1995, 23 (05) : 753 - 760
  • [50] Towards sequence selective DNA binding: design, synthesis and DNA binding studies of novel bis-porphyrin peptidic nanostructures
    Biron, Eric
    Voyer, Normand
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (14) : 2507 - 2515
12345