Synthesis of a novel dimeric bis-benzimidazole with site-selective DNA-binding properties

被引：15
|
作者：
Sun, XW
Neidle, S
Mann, J
机构：
[1] Queens Univ Belfast, Sch Chem, Belfast BT9 5AG, Antrim, North Ireland
[2] Inst Canc Res, Biomol Struct Unit, London SW3 6JB, England
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 40期
关键词：
D O I：
10.1016/S0040-4039(02)01595-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe the synthesis of bis(3-{4-[2'-(4-methoxyphenyl)-3H,3'H-[5,5']bibenzimidazolyl-2-yl]phenoxy} propyl)-methylamine 8, which has high affinity for the oligonucleotide sequence [A.T](4)-[G.C]-[A.T](4). (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码：7239 / 7241
页数：3
相关论文
共 50 条
  • [21] Synthesis and solution complexation behaviour of dimeric zinc-selective bis(benzimidazole) derivatives
    Bates, GB
    Parker, D
    Tasker, PA
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1996, (06): : 1117 - 1125
  • [22] Synthesis, characterization and properties of polyimides derived from a symmetrical diamine containing bis-benzimidazole rings
    Liu, Junpeng
    Zhang, Qinghua
    Xia, Qingming
    Dong, Jie
    Xu, Qian
    POLYMER DEGRADATION AND STABILITY, 2012, 97 (06) : 987 - 994
  • [23] SYNTHESIS, CHARACTERIZATION AND DNA-BINDING PROPERTIES OF NOVEL PLATINUM INTERCALATOR COMPLEXES
    SUNDQUIST, WI
    BANCROFT, DP
    LIPPARD, SJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1988, 196 : 90 - INOR
  • [24] NOVEL SITE-SPECIFIC DNA-BINDING AGENTS
    BRUICE, TC
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 209 : 26 - CARB
  • [25] SYNTHESIS OF A SITE-SPECIFIC DNA-BINDING PEPTIDE
    BRUIST, MF
    HORVATH, SJ
    HOOD, LE
    STEITZ, TA
    SIMON, MI
    SCIENCE, 1987, 235 (4790) : 777 - 780
  • [26] SYNTHESIS AND DNA-BINDING PROPERTIES OF 7-AMINOACTINOMYCIN-D - SELECTIVE FLUORESCENT BINDING AGENT
    SENGUPTA, SK
    TINTER, SK
    RAMSEY, PG
    MODEST, EJ
    VAWTER, GF
    FEDERATION PROCEEDINGS, 1971, 30 (02) : A342 - &
  • [27] Ensemble and single-molecule fluorescence spectroscopic study of the binding modes of the bis-benzimidazole derivative Hoechst 33258 with DNA
    Adhikary, A
    Buschmann, V
    Müller, C
    Sauer, M
    NUCLEIC ACIDS RESEARCH, 2003, 31 (08) : 2178 - 2186
  • [28] SYNTHESIS AND DNA-BINDING PROPERTIES OF POLYAMINE ANALOGS
    EDWARDS, ML
    SNYDER, RD
    STEMERICK, DM
    JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) : 2414 - 2420
  • [29] Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site
    Viger, Anne
    Dervan, Peter B.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (24) : 8539 - 8549
  • [30] Synthesis and evaluation of benzochalcogenazole-benzimidazole derivatives as potential DNA-binding radioprotectors
    Fellowes, Thomas
    Skene, Colin E.
    Martin, Roger F.
    Lobacheysky, Pavel
    Owyong, Tze Cin
    Hong, Yuning
    White, Jonathan M.
    ARKIVOC, 2022, : 80 - 98
12345