Synthesis of a novel dimeric bis-benzimidazole with site-selective DNA-binding properties

被引：15
|
作者：
Sun, XW
Neidle, S
Mann, J
机构：
[1] Queens Univ Belfast, Sch Chem, Belfast BT9 5AG, Antrim, North Ireland
[2] Inst Canc Res, Biomol Struct Unit, London SW3 6JB, England
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 40期
关键词：
D O I：
10.1016/S0040-4039(02)01595-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe the synthesis of bis(3-{4-[2'-(4-methoxyphenyl)-3H,3'H-[5,5']bibenzimidazolyl-2-yl]phenoxy} propyl)-methylamine 8, which has high affinity for the oligonucleotide sequence [A.T](4)-[G.C]-[A.T](4). (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码：7239 / 7241
页数：3
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