Why so narrow: Distribution of anti-sense regulated, type I toxin-antitoxin systems compared with type II and type III systems

被引：23

作者：

Coray, Dorien S. ^{[1
]}

Wheeler, Nicole E. ^{[1
]}

Heinemann, Jack A. ^{[1
,2
]}

Gardner, Paul P. ^{[1
,3
]}

机构：

[1] Univ Canterbury, Sch Biol Sci, Christchurch, New Zealand

[2] Univ Canterbury, Ctr Integrat Ecol, Christchurch, New Zealand

[3] Univ Canterbury, Biomol Interact Ctr, Christchurch, New Zealand

来源：

RNA BIOLOGY | 2017年 / 14卷 / 03期

关键词：

Antisense RNA; horizontal gene transfer; post-segregational killing; toxin-antitoxin systems; PROGRAMMED CELL-DEATH; ESCHERICHIA-COLI; MESSENGER-RNA; LOCI; HOK/SOK; HOK; IDENTIFICATION; TRANSLATION; ACTIVATION; INFECTION;

D O I：

10.1080/15476286.2016.1272747

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toxin-antitoxin (TA) systems are gene modules that appear to be horizontally mobile across a wide range of prokaryotes. It has been proposed that type I TA systems, with an antisense RNA-antitoxin, are less mobile than other TAs that rely on direct toxin-antitoxin binding but no direct comparisons have been made. We searched for type I, II and III toxin families using iterative searches with profile hidden Markov models across phyla and replicons. The distribution of type I toxin families were comparatively narrow, but these patterns weakened with recently discovered families. We discuss how the function and phenotypes of TA systems as well as biases in our search methods may account for differences in their distribution.

引用

页码：275 / 280

页数：6

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