AN EFFICIENT SYNTHESIS OF SOME NEW COUMARIN HYBRIDS ENDOWED WITH EXPECTED BIOLOGICAL ACTIVITY

被引：0
作者：
Raslan, Mohamed A. [1 ]
Hagaggi, Noura Sh [2 ]
Dawood, Kamal M. [3 ]
Atty, Hany A. Abdel [1 ]
Nafady, Ayman [4 ]
机构：
[1] Aswan Univ, Fac Sci, Chem Dept, Aswan 81528, Egypt
[2] Aswan Univ, Fac Sci, Bot Dept, Aswan 81528, Egypt
[3] Cairo Univ, Fac Sci, Chem Dept, Giza 12613, Egypt
[4] King Saud Univ, Coll Sci, Chem Dept, Riyadh, Saudi Arabia
来源：
HETEROCYCLES | 2020年 / 100卷 / 10期
关键词：
Chromene; Malononitrile; Cyanoacetic Acid Hydrazide; FACILE SYNTHESIS; IN-VITRO; DERIVATIVES; ANTIBACTERIAL; ANTIOXIDANT; REACTIVITY; SKELETON; PHENOLS; AGENTS;
D O I：
10.3987/COM-20-14300
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reactions of 5-bromo-2-hydroxybenzaldehyde with cyanoacetic acid hydrazide derivatives in refluxing ethanol afforded some new chromene-based polyfunctionally substituted heteroaromatics. The antimicrobial activity of some of the obtained products was evaluated. The structures of the newly synthesized compounds were elucidated based on their elemental analyses and spectral data.
引用
收藏
页码：1579 / 1598
页数：20
相关论文
共 63 条
  • [51] 2-N
  • [52] Shaker RM, 1996, PHARMAZIE, V51, P148
  • [53] Singleton VL, 1999, METHOD ENZYMOL, V299, P152
  • [54] Bacterial Metabolism and Antibiotic Efficacy
    Stokes, Jonathan M.
    Lopatkin, Allison J.
    Lobritz, Michael A.
    Collins, James J.
    [J]. CELL METABOLISM, 2019, 30 (02) : 251 - 259
  • [55] Synthesis, Biological Evaluation and Docking Studies of 1,3,4-oxadiazole Fused Benzothiazole Derivatives for Anticancer Drugs
    Subramanyam, Madala
    Sreenivasulu, Reddymasu
    Gundla, Rambabu
    Rao, Mandava V. B.
    Rao, Koya Prabhakara
    [J]. LETTERS IN DRUG DESIGN & DISCOVERY, 2018, 15 (12) : 1299 - 1307
  • [56] Turnidge J. D., 2003, SUSCEPTIBILITY TEST, P1103
  • [57] BIOLOGICAL-ACTIVITIES OF A TURKISH MEDICINAL PLANT, PRANGOS-PLATYCHLAENA
    ULUBELEN, A
    TOPCU, G
    TAN, N
    OLCAL, S
    JOHANSSON, C
    UCER, M
    BIRMAN, H
    TAMER, S
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 1995, 45 (03) : 193 - 197
  • [58] VASO K, 2012, NATURA MONTENEGRINA, V11, P93
  • [59] RECENT ADVANCES IN THE SYNTHESIS OF COUMARIN DERIVATIVES VIA KNOEVENAGEL CONDENSATION: A REVIEW
    Vekariya, Rajesh H.
    Patel, Hitesh D.
    [J]. SYNTHETIC COMMUNICATIONS, 2014, 44 (19) : 2756 - 2788
  • [60] An Efficient Synthesis and Antioxidant Properties of Novel Imino and Amino Derivatives of 4-Hydroxy Coumarins
    Vukovic, Nenad
    Sukdolak, Slobodan
    Solujic, Slavica
    Niciforovic, Neda
    [J]. ARCHIVES OF PHARMACAL RESEARCH, 2010, 33 (01) : 5 - 15
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