Endometriosis-associated changes in serum levels of interferons and chemokines

被引：22

作者：

Malutan, Andrei Mihai ^{[1
]}

Drugan, Tudor ^{[2
]}

Ciortea, Razvan

Bucuri, Carmen ^{[1
]}

Rada, Maria Patricia ^{[1
]}

Dan Mihu ^{[1
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, 2nd Obstet & Gynecol Dept, Cluj Napoca, Romania

[2] Iuliu Hatieganu Univ Med & Pharm, Med Informat & Biostatist Dept, Cluj Napoca, Romania

来源：

TURKISH JOURNAL OF MEDICAL SCIENCES | 2017年 / 47卷 / 01期

关键词：

Chemokine; inflammation; endometriosis; interferon; INDUCED PROTEIN-10 CXCL10; NECROSIS-FACTOR-ALPHA; PERITONEAL-FLUID; STROMAL CELLS; WOMEN; INTERLEUKIN-8; CYTOKINES; PATHOGENESIS; EXPRESSION; PROLIFERATION;

D O I：

10.3906/sag-1507-185

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/aim: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. Materials and methods: A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN- alpha, IFN-gamma, MCP- 1, MIP- 1 alpha, MIP- 1 beta, RANTES, eotaxin, IL- 8, MIG, IP- 10, and IL- 17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-gamma, MCP- 1, and IL- 8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP- 10 and eotaxin were significantly lower in women with endometriosis compared to the controls (mean 1.15 and 1.01, respectively, compared to 3.90 and 3.22, respectively). Conclusions. According to our results women with endometriosis have elevated levels IFN-., MCP- 1, and IL- 8, and lower serum levels of IP- 10 and eotaxin, indicating unbalanced immune activity in endometriosis.

引用

页码：115 / 122

页数：8

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