Obesity and atrial fibrillation: A comprehensive review of the pathophysiological mechanisms and links

被引：116
作者：
Goudis, Christos A. [1 ]
Korantzopoulos, Panagiotis [2 ]
Ntalas, Ioannis V. [2 ]
Kallergis, Eleftherios M. [3 ]
Ketikoglou, Dimitrios G. [4 ]
机构：
[1] Gen Hosp Grevena, Dept Cardiol, Grevena, Greece
[2] Univ Ioannina, Sch Med, Dept Cardiol 1, GR-45110 Ioannina, Greece
[3] Univ Hosp Heraklion, Dept Cardiol, Iraklion, Greece
[4] Interbalkan Med Ctr, Dept Cardiol, Thessaloniki, Greece
来源：
JOURNAL OF CARDIOLOGY | 2015年 / 66卷 / 5-6期
关键词：
Obesity; Epicardial adipose tissue; Atrial fibrillation; Atrial remodeling; EPICARDIAL ADIPOSE-TISSUE; OBSTRUCTIVE SLEEP-APNEA; BODY-MASS INDEX; P-WAVE DISPERSION; LEFT-VENTRICULAR HYPERTROPHY; MESENCHYMAL STEM-CELLS; C-REACTIVE PROTEIN; MIDDLE-AGED MEN; METABOLIC SYNDROME; BLOOD-PRESSURE;
D O I：
10.1016/j.jjcc.2015.04.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity is a worldwide health problem with epidemic proportions that has been associated with atrial fibrillation (AF). Even though the underlying pathophysiological mechanisms have not been completely elucidated, several experimental and clinical studies implicate obesity in the initiation and perpetuation of AF. Of note, hypertension, diabetes mellitus, metabolic syndrome, coronary artery disease, and obstructive sleep apnea, represent clinical correlates between obesity and AF. In addition, ventricular adaptation, diastolic dysfunction, and epicardial adipose tissue appear to be implicated in atrial electrical and structural remodeling, thereby promoting the arrhythmia in obese subjects. The present article provides a concise overview of the association between obesity and AF, and highlights the underlying pathophysiological mechanisms. (C) 2015 Published by Elsevier Ltd on behalf of Japanese College of Cardiology.
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收藏
页码：361 / 369
页数：9
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