Dopamine-loaded poly (butyl cyanoacrylate) nanoparticles reverse behavioral deficits in Parkinson's animal models

被引：21

作者：

Jahansooz, Fatemeh ^{[1
]}

Hosseinzade, Bahman Ebrahimi ^{[1
]}

Zarmi, Ashrafalsadat Hatamian ^{[1
]}

Hadi, Fatemeh ^{[2
]}

Hojjati, Seyed Mohammad Massood ^{[3
]}

Shahpasand, Koorosh ^{[2
]}

机构：

[1] Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Tehran, Iran

[2] Royan Inst Stem Cell Biol & Technol ACECR, Cell Sci Res Ctr, Dept Brain & Cognit Sci, Tehran, Iran

[3] Babol Univ Med Sci, Dept Neurol, Babol, Iran

来源：

THERAPEUTIC DELIVERY | 2020年 / 11卷 / 06期

关键词：

dopamine; nanoparticles; Parkinson's disease; poly (butyl cyanoacrylate); BLOOD-BRAIN-BARRIER; DRUG-DELIVERY; DISEASE; ENCAPSULATION; ADSORPTION; DIAGNOSIS; EFFICACY; PRODRUGS; DESIGN; CNS;

D O I：

10.4155/tde-2020-0026

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: Parkinson's disease (PD) is a neurological disorder resulting from decreased dopamine (DA) secretion in the brain, which reflects impaired motor function. Thus, a drug-delivery system for releasing DA into the brain would be of crucial importance. Materials & methods: We herein examined the in vivo drug efficiency of novel poly-butyl-cyanoacrylate nanoparticles loaded with DA (DA-PBCA NPs). Results & conclusion: The NPs were able to pass through the blood-brain barrier and improve brain structure and function in the PD animal models. Moreover, we found a reduced alpha-synucleinopathy in the animal model brains after the NPs administration. Thus, the NPs seem to be a reliable DA delivery system for treating PD patients.

引用

页码：387 / 399

页数：13

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