The effect of treating obstructive sleep apnea with continuous positive airway pressure on posttraumatic stress disorder: A systematic review and meta-analysis with hypothetical model

被引：13

作者：

Zhang, Ye ^{[1
]}

Ren, Rong ^{[1
]}

Yang, Linghui ^{[2
]}

Zhou, Junying ^{[1
]}

Sanford, Larry D. ^{[3
]}

Tang, Xiangdong ^{[1
]}

机构：

[1] Sichuan Univ, Dept Resp & Crit Care Med, State Key Lab Biotherapy,West China Hosp, Sleep Med Ctr,Mental Hlth Ctr,Translat Neurosci C, Dian Xin Nan Jie 28, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Lab Anaesdteisa & Crit Care Med, Translat Neurosci Ctr, State Key Lab Biotherapy,West China Hosp, Chengdu, Sichuan, Peoples R China

[3] Eastern Virginia Med Sch, Dept Anat & Pathol, Sleep Res Lab, POB 1980, Norfolk, VA 23507 USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2019年 / 102卷

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Continuous positive airway pressure; Obstructive sleep apnea; Posttraumatic stress disorder; Nightmare; Meta-analysis; CYCLIC ALTERNATING PATTERN; NASAL CPAP TREATMENT; REM-SLEEP; BLOOD-PRESSURE; PTSD SYMPTOMS; ELECTRICAL-STIMULATION; BASOLATERAL AMYGDALA; STRUCTURAL-CHANGES; CLINICAL-TRIALS; FEAR MEMORY;

D O I：

10.1016/j.neubiorev.2019.03.019

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present study explored whether continuous positive airway pressure (CPAP) treatment impacts nightmare and overall posttraumatic stress disorder (PTSD) symptoms in patients with PTSD and obstructive sleep apnea (OSA). The meta-analysis for six eligibile studies indicates that CPAP can significantly improve nightmare (standardized mean differences (SMD) = -0.778; 95% confidence interval (CI) = -1.228 to -0.327) and overall PTSD symptoms (SMD = -1.298; 95% CI = -2.128 to -0.468) in these patients. A subgroup analysis revealed that the effects of CPAP on improvements of nightmare and overall PTSD symptoms varied across CPAP treatment duration (3 and 6 months), but did not reach a statistically significant level. Furthermore, improvements in overall PTSD symptoms were associated with CPAP adherence. This review emphasizes the importance of the need for a multidisciplinary approach in treating patients with PTSD and OSA, and proposes a hypothetical model of how CPAP improves posttraumatic stress symptoms in patients with PTSD and OSA.

引用

页码：172 / 183

页数：12

共 106 条

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