Medicinal flowers.: VI.: Absolute stereostructures of two new flavanone glycosides and a phenylbutanoid glycoside from the flowers of Chrysanthemum indicum L.:: Their inhibitory activities for rat lens aldose reductase

被引：142

作者：

Matsuda, H ^{[1
]}

Morikawa, T ^{[1
]}

Toguchida, I ^{[1
]}

Harima, S ^{[1
]}

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 07期

关键词：

aldose reductase inhibitor; Chrysanthemum indicum; medicinal flower; (2S)-eriodictyol 7-O-beta-D-glueopyranosiduronic; acid; (2R)-eriodictyol 7-O-beta-D-glucopyranosiduronic acid; (2S,3S)-1-phenyl-2,3-butanediol 3-O-beta-D-glucopyranoside;

D O I：

10.1248/cpb.50.972

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new flavanone glycosides, (2S)- and (2R)-eriodictyol 7-O-beta-D-glucopyranosiduronic acids, and a new phenylbutanoid glycoside, (2S,3S)-1-phenyl-2,3-butanediol 3-O-beta-D-glucopyranoside, were isolated from the flowers of Chrysanthemum indicum L. cultivated in China together with eight flavonoids. The absolute stereostructures of the new compounds were determined on the basis of chemical and physicochemical evidence. Both of the new flavanone glycosides were found to show inhibitory activity for rat lens aldose reductase.

引用

页码：972 / 975

页数：4