An Algorithm for the Noninvasive and Personalized Measurement of Microvascular Blood Viscosity Using Physiological Parameters

被引：8
|
作者：
Sun, Ge [1 ,2 ]
Yang, Lin [1 ,2 ]
Wang, Weiwei [3 ]
Zhang, Song [1 ,2 ]
Luo, Zhichang [1 ,2 ]
Wu, Guanghui [4 ]
Liu, Xiaohong [5 ]
Hao, Dongmei [1 ,2 ]
Yang, Yimin [1 ,2 ]
Li, Xuwen [1 ,2 ]
机构：
[1] Beijing Univ Technol, Fac Environm & Life Sci, Beijing 100124, Peoples R China
[2] Beijing Int Sci & Technol Cooperat Base Intellige, Beijing 100124, Peoples R China
[3] Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
[4] Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China
[5] Beijing Yes Med Devices Co Ltd, Beijing 100152, Peoples R China
来源：
BIOMED RESEARCH INTERNATIONAL | 2020年 / 2020卷
基金：
比尔及梅琳达.盖茨基金会; 国家重点研发计划;
关键词：
ARTERIAL STIFFNESS; FLOW; MODEL; SHEAR;
D O I：
10.1155/2020/7013212
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Blood viscosity is one of the important parameters to characterize hemorheological properties of the human body. Its real-time and dynamic measurement has important physiological significance for studying the development and prevention of chronic diseases. This study researched noninvasive and personalized measurement of microvascular blood viscosity. In the microcirculation capillary network blood flow model, combined with pulse wave parameters, multiple regression analysis was used to fit the simulated radius of personalized physiological blood vessels to calculate the microvascular blood viscosity. The fitted value related to the simulated radius of the physiological blood vessel had a high correlation with the corresponding theoretically derived value (correlation coefficient: 0.904,P <= 0.001). The calculated value of the microvascular blood viscosity had a certain correlation with the clinical whole blood viscosity at a low shear rate (correlation coefficient: 0.443,P<0.05). This algorithm could provide effective means for noninvasive and long-term individual monitoring and family health care.
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页数：7
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