Illuminating liver fibrosis with vitamin D

被引：12

作者：

Firrincieli, D. ^{[1
,2
]}

Braescu, T. ^{[1
,2
]}

Housset, C. ^{[1
,2
,3
]}

Chignard, N. ^{[1
,2
]}

机构：

[1] CdR St Antoine, Inserm UMR S 938, F-75012 Paris, France

[2] UPMC Univ Paris 06, F-75012 Paris, France

[3] Hop St Antoine, AP HP, Serv Hepatol, F-75012 Paris, France

来源：

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2014年 / 38卷 / 01期

基金：

英国医学研究理事会;

关键词：

PRIMARY BILIARY-CIRRHOSIS; D-RECEPTOR POLYMORPHISMS; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR-BETA; D NUCLEAR RECEPTOR; GENETIC ASSOCIATION; EXPRESSION; HEPATITIS; ALPHA; INHIBITION;

D O I：

10.1016/j.clinre.2013.10.004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatic fibrosis results from the accumulation of extracellular matrix-producing myofibroblasts in the liver. The mechanisms leading to the activation of hepatic stellate cells (HSCs) into myofibroblasts have been well described. By contrast, few molecular pathways leading to myofibroblast deactivation have been documented. Recently, the vitamin D-VDR axis has been shown to modulate HSC activity through a complex mechanism involving epigenetic modifications induced by the SMAD pathway. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：5 / 8

页数：4

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