Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

被引：88
作者：
Evans, GB
Furneaux, RH
Gainsford, GJ
Schramm, VL
Tyler, PC
机构：
[1] Ind Res Ltd, Carbohydrate Chem, Lower Hutt, New Zealand
[2] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
来源：
TETRAHEDRON | 2000年 / 56卷 / 19期
基金：
美国国家卫生研究院;
关键词：
carbohydrate mimetics; enzyme inhibitors; nucleosides; purines;
D O I：
10.1016/S0040-4020(00)00194-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Syntheses of the 'Immucillins', potent aza-C-nncleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxyfluoro- and 2-deoxy- analogues and others having modified bases. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3053 / 3062
页数：10
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