The Epinephrine/Norepinephrine/Autoinducer-3 Interkingdom Signaling System in Escherichia coli O157:H7

被引：34

作者：

Moreira, Cristiano G. ^{[1
]}

Sperandio, Vanessa ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Microbiol, 6000 Harry Hines Bvld, Dallas, TX 75390 USA

来源：

MICROBIAL ENDOCRINOLOGY: INTERKINGDOM SIGNALING IN INFECTIOUS DISEASE AND HEALTH, 2ND EDITION | 2016年 / 874卷

关键词：

ENTERICA SEROVAR TYPHIMURIUM; ENTEROCYTE EFFACEMENT GENES; QUORUM-SENSING SIGNAL; SHIGA-LIKE TOXIN; REGULATOR-C QSEBC; TRANSCRIPTIONAL REGULATION; SALMONELLA-TYPHIMURIUM; CONTROLS EXPRESSION; PROTEIN SECRETION; ACTIVATES TRANSCRIPTION;

D O I：

10.1007/978-3-319-20215-0_12

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Epinephrine/norepinephrine/AI-3 signaling is used as an interkingdom chemical signaling system between microbes and their hosts. This system is also exploited by pathogens to regulate virulence traits. In enterohemorrhagic E. coli (EHEC) O157:H7, it is essential for pathogenesis and flagella motility. These three signals activate expression of a pathogenicity island named locus of enterocyte effacement (LEE), Shiga toxin, and the flagella regulon. These signals are sensed by the two-component system QseBC, whereas the bacterial membrane receptor QseC autophosphorylates and phosphorylates the QseB response regulator initiating a complex phosphorelay signaling cascade that activates the expression of a second two-component system, QseEF. The QseEF two-component system is also involved in the expression of the virulence genes, and it senses epinephrine, phosphate, and sulfate. This complex signaling cascade still needs to be completely elucidated.

引用

页码：247 / 261

页数：15

共 75 条

[51] A novel two-component signaling system that activates transcription of an enterohemorrhagic Escherichia coli effector involved in remodeling of host actin [J].