The Epinephrine/Norepinephrine/Autoinducer-3 Interkingdom Signaling System in Escherichia coli O157:H7

被引：34
作者：
Moreira, Cristiano G. [1 ]
Sperandio, Vanessa [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Mol Microbiol, 6000 Harry Hines Bvld, Dallas, TX 75390 USA
来源：
MICROBIAL ENDOCRINOLOGY: INTERKINGDOM SIGNALING IN INFECTIOUS DISEASE AND HEALTH, 2ND EDITION | 2016年 / 874卷
关键词：
ENTERICA SEROVAR TYPHIMURIUM; ENTEROCYTE EFFACEMENT GENES; QUORUM-SENSING SIGNAL; SHIGA-LIKE TOXIN; REGULATOR-C QSEBC; TRANSCRIPTIONAL REGULATION; SALMONELLA-TYPHIMURIUM; CONTROLS EXPRESSION; PROTEIN SECRETION; ACTIVATES TRANSCRIPTION;
D O I：
10.1007/978-3-319-20215-0_12
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Epinephrine/norepinephrine/AI-3 signaling is used as an interkingdom chemical signaling system between microbes and their hosts. This system is also exploited by pathogens to regulate virulence traits. In enterohemorrhagic E. coli (EHEC) O157:H7, it is essential for pathogenesis and flagella motility. These three signals activate expression of a pathogenicity island named locus of enterocyte effacement (LEE), Shiga toxin, and the flagella regulon. These signals are sensed by the two-component system QseBC, whereas the bacterial membrane receptor QseC autophosphorylates and phosphorylates the QseB response regulator initiating a complex phosphorelay signaling cascade that activates the expression of a second two-component system, QseEF. The QseEF two-component system is also involved in the expression of the virulence genes, and it senses epinephrine, phosphate, and sulfate. This complex signaling cascade still needs to be completely elucidated.
引用
收藏
页码：247 / 261
页数：15
相关论文
共 75 条
[41]   A GENETIC-LOCUS OF ENTEROCYTE EFFACEMENT CONSERVED AMONG DIVERSE ENTEROBACTERIAL PATHOGENS [J].
MCDANIEL, TK ;
JARVIS, KG ;
DONNENBERG, MS ;
KAPER, JB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1664-1668
[42]   A novel proline-rich protein, EspF, is secreted from enteropathogenic Escherichia coli via the type III export pathway [J].
McNamara, BP ;
Donnenberg, MS .
FEMS MICROBIOLOGY LETTERS, 1998, 166 (01) :71-78
[43]   Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function [J].
McNamara, BP ;
Koutsouris, A ;
O'Connell, CB ;
Nougayréde, JP ;
Donnenberg, MS ;
Hecht, G .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (05) :621-629
[44]   The Per regulon of enteropathogenic Escherichia coli:: identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement (LEE)-encoded regulator (Ler) [J].
Mellies, JL ;
Elliott, SJ ;
Sperandio, V ;
Donnenberg, MS ;
Kaper, JB .
MOLECULAR MICROBIOLOGY, 1999, 33 (02) :296-306
[45]   Role of Salmonella enterica serovar typhimurium two-component system PreA/PreB in modulating PmrA-regulated gene transcription [J].
Merighi, M ;
Carroll-Portillo, A ;
Septer, AN ;
Bhatiya, A ;
Gunn, JS .
JOURNAL OF BACTERIOLOGY, 2006, 188 (01) :141-149
[46]   Genome-wide analysis of the PreA/PreB (QseB/QseC) regulon of Salmonella enterica serovar Typhimurium [J].
Merighi, Massimo ;
Septer, Alecia N. ;
Carroll-Portillo, Amanda ;
Bhatiya, Aditi ;
Porwollik, Steffen ;
McClelland, Michael ;
Gunn, John S. .
BMC MICROBIOLOGY, 2009, 9
[47]   Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal Al-2 [J].
Miller, ST ;
Xavier, KB ;
Campagna, SR ;
Taga, ME ;
Semmelhack, MF ;
Bassler, BL ;
Hughson, FM .
MOLECULAR CELL, 2004, 15 (05) :677-687
[48]   Functional and genetic analysis of regulatory regions of coliphage H-19B: location of shiga-like toxin and lysis genes suggest a role for phage functions in toxin release [J].
Neely, MN ;
Friedman, DI .
MOLECULAR MICROBIOLOGY, 1998, 28 (06) :1255-1267
[49]   ISOLATION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES TO SHIGA-LIKE TOXIN-II OF ENTEROHEMORRHAGIC ESCHERICHIA-COLI AND USE OF THE MONOCLONAL-ANTIBODIES IN A COLONY ENZYME-LINKED IMMUNOSORBENT-ASSAY [J].
PERERA, LP ;
MARQUES, LRM ;
OBRIEN, AD .
JOURNAL OF CLINICAL MICROBIOLOGY, 1988, 26 (10) :2127-2131
[50]   Targeting QseC signaling and virulence for antibiotic development [J].
Rasko, David A. ;
Moreira, Cristiano G. ;
Li, De Run ;
Reading, Nicola C. ;
Ritchie, Jennifer M. ;
Waldor, Matthew K. ;
Williams, Noelle ;
Taussig, Ron ;
Wei, Shuguang ;
Roth, Michael ;
Hughes, David T. ;
Huntley, Jason F. ;
Fina, Maggy W. ;
Falck, John R. ;
Sperandio, Vanessa .
SCIENCE, 2008, 321 (5892) :1078-1080
12345678