varDB: common ground for a shifting landscape

被引：2

作者：

Allred, David R. ^{[1
,2
,3
]}

Barbet, Anthony F. ^{[1
,2
,3
]}

Barry, J. David ^{[4
]}

Deitsch, Kirk W. ^{[5
]}

机构：

[1] Univ Florida, Dept Infect Dis & Pathol, Gainesville, FL 32611 USA

[2] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA

[3] Univ Florida, Genet Inst, Gainesville, FL 32610 USA

[4] Univ Glasgow, Wellcome Ctr Mol Parasitol, Glasgow G12 8TA, Lanark, Scotland

[5] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA

来源：

TRENDS IN PARASITOLOGY | 2009年 / 25卷 / 06期

基金：

英国惠康基金;

关键词：

MEMBRANE PROTEIN GENES; VES MULTIGENE FAMILY; ANTIGENIC VARIATION; MALARIA; EXPRESSION; HETEROGENEITY; VIRULENCE; LOCUS;

D O I：

10.1016/j.pt.2009.03.003

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Antigenic variation is a phylogenetically widespread phenomenon thought to lead to survival benefits for the pathogen. Although governed by genetic mechanisms, antigenic variation is ultimately manifested in variant proteins. The varDB database is an attempt to gain an overview of common structures and functions of variant proteins related to enhanced survival. varDB provides a wealth of sequence data and several tools to facilitate their analysis, but current limitations preclude achievement of its full promise. A critique of this database and how it could serve the scientific community is provided here.

引用

页码：249 / 252

页数：4

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