Management of proton pump inhibitor responsive-esophageal eosinophilia and eosinophilic esophagitis: controversies in treatment approaches

被引：2

作者：

Kochar, Bharati ^{[1
]}

Dellon, Evan S. ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Ctr Esophageal Dis & Swallowing, Dept Med,Div Gastroenterol & Hepatol, Chapel Hill, NC 27599 USA

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2015年 / 9卷 / 11期

关键词：

challenges; endoscopy; eosinophilic esophagitis; management; proton pump inhibitor responsive esophageal eosinophilia; PLACEBO-CONTROLLED TRIAL; 6-FOOD ELIMINATION DIET; TOPICAL CORTICOSTEROIDS; FLUTICASONE PROPIONATE; STEROID-THERAPY; ADULT PATIENTS; INTRAEPITHELIAL EOSINOPHILS; CONSENSUS RECOMMENDATIONS; SWALLOWED FLUTICASONE; INHALED CICLESONIDE;

D O I：

10.1586/17474124.2015.1088384

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Eosinophilic esophagitis (EoE) is a chronic immune-mediated clinicopathologic disease. The prevalence of EoE is approximately 1/2000 persons, EoE is now the most common cause of food impactions, with healthcare expenditures approaching US$ 1 billion annually. This article will discuss challenges related to proton pump inhibitor responsive esophageal eosinophilia, including distinguishing this condition from EoE and understanding the mechanisms behind the PPI response. For EoE, we will review multiple ongoing debates about treatment and monitoring strategies, including selecting treatment outcomes, optimizing medication formulations, approaching the steroid-refractory patient, conducting dietary elimination, prescribing long-term maintenance therapy and performing esophageal dilation.

引用

页码：1359 / 1369

页数：11

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