Retrospective analysis of off-label medication use at a plastic surgery hospital in China and evidence-based evaluation

被引:4
作者
Gao, Zhi [1 ]
Jiao, Rui [1 ]
Zhang, Wei [1 ]
Guo, Wei [1 ]
Li, Wei [1 ]
Shi, Chen [1 ]
Liu, Fang [1 ]
Zhang, Yi [1 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Plast Surg Hosp Inst, Dept Pharm, 33 Badachu Rd, Beijing 100144, Peoples R China
关键词
dermatology; evidence; off‐ label; plastic surgery; review; PHOTODYNAMIC THERAPY; ORAL ISOTRETINOIN; KELOID TREATMENT; BOTULINUM TOXIN; TRANEXAMIC ACID; DOUBLE-BLIND; ACNE; GLUTATHIONE; ACITRETIN; VITILIGO;
D O I
10.1111/dth.14424
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
To retrospectively analyze the off-label prescriptions at a plastic surgery hospital in China and conduct a literature review. The prescriptions in outpatient department from January 1, 2018 to December 31, 2018 were collected and compared with the related drug instructions in indications, dosage, frequency and route of administration to identify the off-label prescriptions. According to related literatures, guidelines, and MICROMEDEX, the rationality of off-label drug uses was evaluated. A total of 39 836 prescriptions were screened and 3395 (8.52%) off-label prescriptions were identified. It involved 23 items off-label medication uses. 20 items were off-label used in indication and three items were in indication and administration route. These off-label prescriptions involved 19 medicines and 12 indications and the dermatology related drug usage accounted for the largest proportion (91.3%). Additionally, five items (21.7%) were Chinese patent medicine related. Of the 23 items, seven (30.4%) have been recommended by guidelines and two (8.7%) by Thomson Grading System of Micromedex. All of them have been proved by literature evidence of level 1 to 4, in which 19 (82.6%) by Level 1 evidence, 21 (91.3%) by Level 1 to 2 evidence and 2 (8.7%) only by level 3 to 4 evidence. This can provide a theoretical basis to clinicians in prescribing. Our next work is to perfect some details about evidence assessment to improve the reliability.
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页数:12
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共 48 条
[1]   Glutathione as an oral whitening agent: A randomized, double-blind, placebo-controlled study [J].
Arjinpathana, Nutthavuth ;
Asawanonda, Pravit .
JOURNAL OF DERMATOLOGICAL TREATMENT, 2012, 23 (02) :97-102
[2]   Comparative Efficacy and Safety of Common Therapies in Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis [J].
Bao, Yawei ;
Xu, Shanshan ;
Pan, Zhipeng ;
Deng, Jixiang ;
Li, Xinyi ;
Pan, Faming ;
Li, Xiaojing .
AESTHETIC PLASTIC SURGERY, 2020, 44 (01) :207-218
[3]   Light therapies for acne [J].
Barbaric, Jelena ;
Abbott, Rachel ;
Posadzki, Pawel ;
Car, Mate ;
Gunn, Laura H. ;
Layton, Alison M. ;
Majeed, Azeem ;
Car, Josip .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2016, (09)
[4]   Italian consensus report on the aesthetic use of onabotulinum toxin A [J].
Bertossi, Dario ;
Cavallini, Maurizio ;
Cirillo, Pierfrancesco ;
Piero Fundaro, Salvatore ;
Quartucci, Sandro ;
Sciuto, Chantal ;
Tonini, Davide ;
Trocchi, Gloria ;
Signorini, Massimo .
JOURNAL OF COSMETIC DERMATOLOGY, 2018, 17 (05) :719-730
[5]   Intralesional 5-Fluorouracil in Keloid Treatment: A Systematic Review [J].
Bijlard, Eveline ;
Steltenpool, Sanne ;
Niessen, Frank B. .
ACTA DERMATO-VENEREOLOGICA, 2015, 95 (07) :778-782
[6]   The Role of Photodynamic Therapy in Acne: An Evidence-Based Review [J].
Boen, Monica ;
Brownell, Joshua ;
Patel, Priyanka ;
Tsoukas, Maria M. .
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2017, 18 (03) :311-321
[7]   Can retinoids flare hidradenitis suppurativa? A further case series [J].
Caro, R. D. Caposiena ;
Bianchi, L. .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2019, 44 (04) :E153-E154
[8]   Maintenance Therapy of Adult Vitiligo with 0.1% Tacrolimus Ointment: A Randomized, Double Blind, Placebo-Controlled Study [J].
Cavalie, Marine ;
Ezzedine, Khaled ;
Fontas, Eric ;
Montaudie, Henri ;
Castela, Emeline ;
Bahadoran, Philippe ;
Taieb, Alain ;
Lacour, Jean-Philippe ;
Passeron, Thierry .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (04) :970-974
[9]   Duration of effectiveness of Botulinum toxin type A in excessive gingival display: a systematic review and meta-analysis [J].
Chagas, Taisa Figueiredo ;
de Almeida, Natalia Valli ;
Lisboa, Cinthia Oliveira ;
Tavares Pereira Ferreira, Daniele Masterson ;
Mattos, Claudia Trindade ;
Mucha, Jose Nelson .
BRAZILIAN ORAL RESEARCH, 2018, 32
[10]   Treatment of Hyaluronic Acid Filler-Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations [J].
Cohen, Joel L. ;
Biesman, Brian S. ;
Dayan, Steven H. ;
DeLorenzi, Claudio ;
Lambros, Val S. ;
Nestor, Mark S. ;
Sadick, Neil ;
Sykes, Jonathan .
AESTHETIC SURGERY JOURNAL, 2015, 35 (07) :844-849