Use of Calcium Isotopic Tracers To Determine Factors That Perturb Calcium Metabolism

被引：8

作者：

Cao, Sisi ^{[1
]}

Cladis, Dennis P. ^{[2
]}

Weaver, Connie M. ^{[2
]}

机构：

[1] Purdue Univ, Dept Nutr Sci, W Lafayette, IN 47907 USA

[2] Purdue Univ, Dept Food Sci, W Lafayette, IN 47907 USA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2020年 / 68卷 / 46期

关键词：

calcium metabolism; isotopic tracers; prebiotics; gut microbiota;

D O I：

10.1021/acs.jafc.0c01641

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Calcium plays an important role in maintaining bone health. Ensuring adequate calcium intake throughout life is essential for reaching greater peak bone mass in young adulthood and lowering osteoporotic fracture risk when aging. Calcium homeostasis involves a complex interaction between three organ systems: intestine, kidney, and bone. Metabolic balance plus kinetic studies using calcium isotopic tracers can estimate calcium metabolism parameters and pinpoint how organs and processes are perturbed by internal and external modifiers. Both modifiable factors (e.g., vitamin D supplementations and dietary bioactives) and non-modifiable factors (e.g., age, sex, and race) influence calcium utilization. Current evidence suggests that prebiotic fibers may offer an alternative approach to enhance calcium absorption through altering gut microbiota to ultimately improve bone health.

引用

页码：12886 / 12892

页数：7

共 63 条

[1] A randomized controlled trial of vitamin D3 supplementation in African American women [J].