Ocular vestibular evoked myogenic potential frequency tuning in certain Meniere's disease

Ocular vestibular evoked myogenic potentials (oVEMP) represent extraocular muscle activity in response to vestibular stimulation. To specify the value of oVEMP in the diagnostics of Meniere's disease, the amplitude ratio between 500 and 1000 Hz stimuli was investigated. Thirty-nine patients with certain Meniere's disease, i.e. definite Meniere's disease with visualization of endolymphatic hydrops by magnetic resonance imaging and 49 age-matched healthy controls were enrolled in this study. oVEMP were recorded using 500 and 1000 Hz air-conducted tone bursts. For Meniere's ears, the 500/1000 Hz amplitude ratio (mean ratio = 1.20) was significantly smaller when compared to unaffected ears of Meniere's patients (mean ratio = 1.80; p = 0.008) or healthy controls (mean ratio = 1.81; p = 0.011). The amplitude ratio was neither correlated with the degree of endolymphatic hydrops nor with the duration of disease. While an older age was associated with a diminished amplitude ratio in healthy controls, there was no correlation between the amplitude ratio and age in Meniere's ears. Hence, the calculation of the oVEMP 500/1000 Hz amplitude ratio may be a valuable diagnostic tool for Meniere's disease. (C) 2014 Elsevier B.V. All rights reserved.