Arylboration of Alkenes by Cooperative Palladium/Copper Catalysis

被引：189

作者：

Semba, Kazuhiko ^{[1
]}

Nakao, Yoshiaki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Mat Chem, Kyoto 6158510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 21期

关键词：

COUPLING REACTIONS; BORONIC ESTERS; ARYL IODIDES; ENANTIOSELECTIVE SYNTHESIS; ARYLBORONIC ACIDS; ROOM-TEMPERATURE; EFFICIENT ROUTE; ALKYNES; CARBOBORATION; HALIDES;

D O I：

10.1021/ja5029556

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Arylboration of vinylarenes and methyl crotonate with aryl halides and bis(pinacolato)diboron by cooperative Pd/Cu catalysis has been developed, giving 2-boryl-1,1-diarylethanes and an alpha-aryl-beta-boryl ester in a regioselective manner. The reaction is compatible with a variety of functionalities and amenable to be scaled-up to a gram scale with no detriment to the yield. A short synthesis of the biologically active compound CDP840 was performed using the present reaction as a key step.

引用

页码：7567 / 7570

页数：4

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