Ability of Low Antihypertensive Medication Adherence to Predict Statin Discontinuation and Low Statin Adherence in Patients Initiating Treatment After a Coronary Event

被引：33

作者：

Muntner, Paul ^{[1
]}

Yun, Huifeng ^{[1
]}

Sharma, Pradeep ^{[1
]}

Delzell, Elizabeth ^{[1
]}

Kent, Shia T. ^{[1
]}

Kilgore, Meredith L. ^{[2
]}

Farkouh, Michael E. ^{[4
]}

Vupputuri, Suma ^{[5
]}

Bittner, Vera ^{[3
]}

Rosenson, Robert S. ^{[4
]}

Levitan, Emily B. ^{[1
]}

Safford, Monika M. ^{[3
]}

机构：

[1] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35203 USA

[2] Univ Alabama Birmingham, Dept Hlth Care Org & Policy, Birmingham, AL USA

[3] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[4] Mt Sinai Sch Med, Dept Med, New York, NY USA

[5] Kaiser Permanente Georgia, Div Res, Atlanta, GA USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2014年 / 114卷 / 06期

关键词：

BLOOD-PRESSURE CONTROL; HEART-DISEASE; HYPERTENSION; TRENDS; MORTALITY; THERAPY; RATES;

D O I：

10.1016/j.amjcard.2014.06.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low statin adherence and discontinuation of statins are common in patients with coronary heart disease. We hypothesized that low antihypertensive medication adherence would be associated with future statin discontinuation and low adherence in patients initiating statins. Using a 5% national sample of Medicare beneficiaries, we conducted a cohort study of Medicare beneficiaries initiating statins after hospitalization for acute myocardial infarction or coronary revascularization in 2007, 2008, and 2009. Antihypertensive medication adherence, defined using the average proportion of days covered across 5 classes during the 365 days before hospitalization, was categorized as >= 80% (high), 50% to <80% (medium), and <50% (low). Stalin discontinuation was defined as failure to refill a statin within 365 days of hospital discharge, and low adherence was defined as proportion of days covered for statins <80%. In 2,695 Medicare beneficiaries who initiated statins after hospital discharge, 6.0%, 8.4%, and 14.5% with high, medium, and low antihypertensive medication adherence discontinued statins. After multivariable adjustment, the risk ratios (95% confidence interval) for statin discontinuation were 1.38 (0.98 to 1.95) and 2.41 (1.51 to 3.87) for beneficiaries with medium and low versus high antihypertensive medication adherence, respectively. In beneficiaries who did not discontinue statins, 36.2% had low statin adherence. Compared with high adherence, medium and low antihypertensive medication adherences were associated with multivariable adjusted risk ratios (95% confidence interval) for low statin adherence of 1.33 (1.14 to 1.55) and 1.62 (1.25 to 2.10), respectively. In conclusion, low antihypertensive medication adherence before initiating statins is associated with future statin discontinuation and low statin adherence. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：826 / 831

页数：6

共 28 条

[1] Abughosh Susan M, 2004, J Manag Care Pharm, V10, P404
[2] [Anonymous], USRDS 2009 ANN DAT R
[3] Long-term persistence in use of statin therapy in elderly patients
Benner, JS
Glynn, RJ
Mogun, H
Neumann, PJ
Weinstein, MC
Avorn, J
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (04): : 455 - 461
[4] Cardiovascular morbidity associated with nonadherence to statin therapy
Blackburn, DE
Dobson, RT
Blackburn, JL
Wilson, TW
[J]. PHARMACOTHERAPY, 2005, 25 (08): : 1035 - 1043
[5] Applying qualitative methods in developing a culturally tailored workbook for black patients with hypertension
Boutin-Foster, C.
Ravenell, Joseph E.
Greenfield, V. W.
Medmim, B.
Ogedegbe, G.
[J]. PATIENT EDUCATION AND COUNSELING, 2009, 77 (01) : 144 - 147
[6] Impact of decreasing copayments on medication adherence within a disease management environment
Chernew, Michael E.
Shah, Mayur R.
Wegh, Arnold
Rosenberg, Stephen N.
Juster, Iver A.
Rosen, Allison B.
Sokol, Michael C.
Yu-Isenberg, Kristina
Fendrick, A. Mark
[J]. HEALTH AFFAIRS, 2008, 27 (01) : 103 - 112
[7] Full Coverage for Preventive Medications after Myocardial Infarction
Choudhry, Niteesh K.
Avorn, Jerry
Glynn, Robert J.
Antman, Elliott M.
Schneeweiss, Sebastian
Toscano, Michele
Reisman, Lonny
Fernandes, Joaquim
Spettell, Claire
Lee, Joy L.
Levin, Raisa
Brennan, Troyen
Shrank, William H.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (22) : 2088 - 2097
[8] Choudhry NK, 2009, AM J MANAG CARE, V15, P457
[9] Eaddy Michael T, 2012, P T, V37, P45
[10] Heart Disease and Stroke Statistics-2013 Update A Report From the American Heart Association
Go, Alan S.
Mozaffarian, Dariush
Roger, Veronique L.
Benjamin, Emelia J.
Berry, Jarett D.
Borden, William B.
Bravata, Dawn M.
Dai, Shifan
Ford, Earl S.
Fox, Caroline S.
Franco, Sheila
Fullerton, Heather J.
Gillespie, Cathleen
Hailpern, Susan M.
Heit, John A.
Howard, Virginia J.
Huffman, Mark D.
Kissela, Brett M.
Kittner, Steven J.
Lackland, Daniel T.
Lichtman, Judith H.
Lisabeth, Lynda D.
Magid, David
Marcus, Gregory M.
Marelli, Ariane
Matchar, David B.
McGuire, Darren K.
Mohler, Emile R.
Moy, Claudia S.
Mussolino, Michael E.
Nichol, Graham
Paynter, Nina P.
Schreiner, Pamela J.
Sorlie, Paul D.
Stein, Joel
Turan, Tanya N.
Virani, Salim S.
Wong, Nathan D.
Woo, Daniel
Turner, Melanie B.
[J]. CIRCULATION, 2013, 127 (01) : E6 - E245

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