Fecal Microbiota Transplantation Inducing Remission in Crohn's Colitis and the Associated Changes in Fecal Microbial Profile

被引：80

作者：

Kao, Dina ^{[1
]}

Hotte, Naomi ^{[1
]}

Gillevet, Patrick ^{[2
]}

Madsen, Karen ^{[1
]}

机构：

[1] Univ Alberta, Dept Med, Edmonton, AB T6G2X8, Canada

[2] George Mason Univ, Dept Environm Sci & Policy, Manassa, VA USA

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 2014年 / 48卷 / 07期

关键词：

inflammatory bowel disease (IBD); fecal microbiota transplantation (FMT); mucosal healing; dysbiosis; INFLAMMATORY-BOWEL-DISEASE; ULCERATIVE-COLITIS; CLOSTRIDIUM-DIFFICILE; SAFETY; FLORA;

D O I：

10.1097/MCG.0000000000000131

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the intestine of unclear etiology. Increasing evidence has pointed to intestinal dysbiosis as a potential factor in a genetically susceptible individual. Fecal microbiota transplantation (FMT) has been used to treat inflammatory bowel disease with variable degrees of success. Herein, we report a patient with Crohn's colitis, previously failing an immunosuppressant, who achieved clinical, endoscopic, and histologic remission after a single fecal microbiota transplantation infusion. We have further characterized the changes in the fecal microbiota associated with this observation.

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页码：625 / 628

页数：4

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