Cytogenetic abnormalities in 179 cases with male infertility in Western Region of Turkey: Report and review

被引：21

作者：

Akgul, M. ^{[1
]}

Ozkinay, F. ^{[1
]}

Ercal, D. ^{[2
]}

Cogulu, O. ^{[1
]}

Dogan, O. ^{[3
]}

Altay, B. ^{[4
]}

Tavmergen, E. ^{[5
]}

Gunduz, C. ^{[3
]}

Ozkinay, C. ^{[1
]}

机构：

[1] Ege Univ, Dept Med Genet, Fac Med, Izmir, Turkey

[2] Dokuz Eylul Univ, Fac Med, Dept Med Genet, Izmir, Turkey

[3] Ege Univ, Dept Med Biol, Fac Med, Izmir, Turkey

[4] Ege Univ, Dept Urol, Fac Med, Izmir, Turkey

[5] Family Planning Infertil Res & Treatment Ctr, Izmir, Turkey

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2009年 / 26卷 / 2-3期

关键词：

Male infertility; Chromosomal abnormality; INTRACYTOPLASMIC SPERM INJECTION; CHROMOSOMAL-ABNORMALITIES; NONOBSTRUCTIVE AZOOSPERMIA; PERICENTRIC INVERSIONS; MEN; COUPLES; OLIGOZOOSPERMIA; PREVALENCE; ANOMALIES;

D O I：

10.1007/s10815-009-9296-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this study we aimed to evaluate the postnatally screened karyotype results in couples who were referred because of primary infertility between 2000 and 2006 in Izmir. The records of a total of 179 cases were evaluated retrospectively. A total of 21 cases (11.74%) showed chromosomal alteration. Thirteen (7.26%) were 47,XXY; three (1.68%) were pericentric inversion of chromosome 9; one (0.56%) 46,XY/45,XO; one (0.56%) 46,XY/47,XXY/48,XXXY; one (0.56%) 46,XY,t(X;1); one (0.56%) 46,XY/46,XY,del(Y)(q11.2) and one (0.56%) 46,XX. The rate of gonosomal chromosomal abnormalities was nearly three times higher in our region than the rate in the literature. Chromosomal analysis is strongly suggested particularly in those who suffer fertility problems.

引用

页码：119 / 122

页数：4

共 25 条

[1] Genetic screening for patients with azoospermia and severe oligo-asthenospermia
Chiang, HS
Wei, HJ
Chen, YT
[J]. INTERNATIONAL JOURNAL OF ANDROLOGY, 2000, 23 : 20 - 25
[2] Prevalence of chromosomal abnormalities in 2078 infertile couples referred for assisted reproductive techniques
Clementini, E
Palka, C
Iezzi, I
Stuppia, L
Guanciali-Franchi, P
Tiboni, GM
[J]. HUMAN REPRODUCTION, 2005, 20 (02) : 437 - 442
[3] DELACHAPELLE A, 1974, AM J HUM GENET, V26, P746
[4] Genetic risk factors in infertile men with severe oligozoospermia and azoospermia
Dohle, GR
Halley, DJJ
Van Hemel, JO
van den Ouwel, AMW
Pieters, MHEC
Weber, RFA
Govaerts, LCP
[J]. HUMAN REPRODUCTION, 2002, 17 (01) : 13 - 16
[5] Genetic causes of male infertility
Ferlin, Alberto
Arredi, Barbara
Foresta, Carlo
[J]. REPRODUCTIVE TOXICOLOGY, 2006, 22 (02) : 133 - 141
[6] Cytogenetic study in 102 infertile men
Gündüz, G
Lüleci, G
Baykara, M
[J]. UROLOGIA INTERNATIONALIS, 1998, 61 (01) : 32 - 34
[7] Genetic evaluation of infertile men
Kleiman, SE
Yogev, L
Gamzu, R
Hauser, R
Botchan, A
Lessing, JB
Paz, G
Yavetz, H
[J]. HUMAN REPRODUCTION, 1999, 14 (01) : 33 - 38
[8] Genital anomalies in Klinefelter's syndrome
Lee, Yung Seng
Cheng, Anna Wai Fun
Ahmed, Syed Faisal
Shaw, Nick J.
Hughes, Ieuan A.
[J]. HORMONE RESEARCH, 2007, 68 (03) : 150 - 155
[9] Cytogenetic analyses in infertile men
Lissitsina, J
Mikelsaar, R
Punab, M
[J]. ARCHIVES OF ANDROLOGY, 2006, 52 (02): : 91 - 95
[10] Mau UA, 1997, HUM REPROD, V12, P930

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