Calcium Signaling in Vascular Smooth Muscle Cells: From Physiology to Pathology

被引：25

作者：

Marchand, Alexandre ^{[1
]}

Abi-Gerges, Aniella ^{[1
]}

Saliba, Youakim ^{[1
]}

Merlet, Elise ^{[1
]}

Lompre, Anne-Marie ^{[1
]}

机构：

[1] Univ Paris 06, Inserm UMRS 956, F-75013 Paris, France

来源：

CALCIUM SIGNALING | 2012年 / 740卷

关键词：

Calcium signaling; Excitation-contraction; Excitation-transcription; microRNA; Physiopathology; Vascular smooth muscle; ELEMENT-BINDING PROTEIN; CAPACITATIVE CA2+ ENTRY; ACTIVATED T-CELLS; NEOINTIMA FORMATION; DOWN-REGULATION; IN-VIVO; CARDIAC-HYPERTROPHY; RYANODINE RECEPTORS; NA+/CA2+ EXCHANGER; CATION CHANNELS;

D O I：

10.1007/978-94-007-2888-2_35

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cyclic variations in calcium (Ca2+) concentrations, through a process called excitation-contraction coupling, allow regulation of vascular smooth muscle cells contractility and thus modulation of vascular tone and blood pressure. As a second messenger, Ca2+ also activates signaling cascades leading to transcription factors activation in a process called excitation-transcription coupling. Furthermore, recent evidences indicate an interaction between post-transcriptional regulation by microRNAs (miRNAs) and Ca2+ signaling. All these actors, which are frequently altered in vascular diseases, will be reviewed here.

引用

页码：795 / 810

页数：16

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