Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.

被引：55
作者：
Huang, XC
Zhao, D
Guo, YW [1 ]
Wu, HM
Lin, LP
Wang, ZH
Ding, J
Lin, YS
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Zu Chong Zhi Rd 555,Zhangjiang High Tech Pk, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 12期
关键词：
dinoflagellate; Amphidinium sp; lingshuiol; antitumor;
D O I：
10.1016/j.bmcl.2004.04.029
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel polyhydroxy compound with a linear carbon-chain, lingshuiol (1), had been isolated from the cultured marine dinoflagellate Amphidinium sp. Its structure was elucidated by extensive analysis of 2D NMR spectral data. Lingshuiol possessed a powerful cytotoxic activity against A-549 and HL-60 cells in vitro with the IC50 of 0.21 and 0.23 muM, respectively. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：3117 / 3120
页数：4
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