Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.

被引：55

作者：

Huang, XC

Zhao, D

Guo, YW ^{[1
]}

Wu, HM

Lin, LP

Wang, ZH

Ding, J

Lin, YS

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Zu Chong Zhi Rd 555,Zhangjiang High Tech Pk, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 12期

关键词：

dinoflagellate; Amphidinium sp; lingshuiol; antitumor;

D O I：

10.1016/j.bmcl.2004.04.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel polyhydroxy compound with a linear carbon-chain, lingshuiol (1), had been isolated from the cultured marine dinoflagellate Amphidinium sp. Its structure was elucidated by extensive analysis of 2D NMR spectral data. Lingshuiol possessed a powerful cytotoxic activity against A-549 and HL-60 cells in vitro with the IC50 of 0.21 and 0.23 muM, respectively. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3117 / 3120

页数：4

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