Current and Promising Antivirals Against Chikungunya Virus

被引：29
作者：
Hucke, Friederike I. L. [1 ]
Bugert, Joachim J. [1 ]
机构：
[1] Bundeswehr Inst Microbiol, Dept Virol, Munich, Germany
来源：
FRONTIERS IN PUBLIC HEALTH | 2020年 / 8卷
关键词：
antiviral design; CHIKV therapy; direct antiviral action; host-targeting antiviral; comparison of in vitro efficacies; favipiravir; ribavirin; PROTEIN-KINASE-C; SMALL-MOLECULE INHIBITORS; STRAND RNA VIRUSES; MYCOPHENOLIC-ACID; IN-VITRO; EQUINE ENCEPHALITIS; NATURAL-PRODUCTS; POTENT INHIBITOR; PHORBOL ESTERS; SINDBIS VIRUS;
D O I：
10.3389/fpubh.2020.618624
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Chikungunya virus (CHIKV) is the causative agent of chikungunya fever (CHIKF) and is categorized as a(n) (re)emerging arbovirus. CHIKV has repeatedly been responsible for outbreaks that caused serious economic and public health problems in the affected countries. To date, no vaccine or specific antiviral therapies are available. This review gives a summary on current antivirals that have been investigated as potential therapeutics against CHIKF. The mode of action as well as possible compound targets (viral and host targets) are being addressed. This review hopes to provide critical information on the in vitro efficacies of various compounds and might help researchers in their considerations for future experiments.
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页数：23
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