FAS and FAS Ligand Polymorphisms in the Promoter Regions and Risk of Gastric Cancer in Southern China

被引：29
|
作者：
Wang, Meilin [2 ]
Wu, Dongmei [2 ]
Tan, Ming [3 ]
Gong, Weida [4 ]
Xue, Hengchuan [4 ]
Shen, Hongbin [1 ]
Zhang, Zhengdong [1 ,2 ]
机构：
[1] Nanjing Med Univ, Ctr Canc, Dept Epidemiol & Stat, Nanjing, Peoples R China
[2] Nanjing Med Univ, Ctr Canc, Dept Mol & Genet Toxicol, Nanjing 210029, Peoples R China
[3] Yangzhong Canc Res Inst, Yangzhong, Jiangsu, Peoples R China
[4] Yixing Peoples Hosp, Yixing, Jiangsu, Peoples R China
来源：
BIOCHEMICAL GENETICS | 2009年 / 47卷 / 7-8期
基金：
中国国家自然科学基金;
关键词：
FAS; FAS ligand; Gastric cancer; Susceptibility; Molecular epidemiology; PATHWAY GENES FAS; FUNCTIONAL POLYMORPHISMS; HAPLOTYPE RECONSTRUCTION; BLADDER-CANCER; CELL-DEATH; APOPTOSIS; DISEQUILIBRIUM; EXPRESSION;
D O I：
10.1007/s10528-009-9264-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The FAS and FAS ligand (FASLG) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis. Functional promoter polymorphisms of the FAS and FASLG genes can alter transcriptional activities and thus alter risk of cancer. We hypothesized that the FAS -1377G > A, FAS -670A > G, and FASLG -844T > C polymorphisms in the promoter regions are associated with risk of gastric cancer. In a population-based case-control study of 332 gastric cancer cases and 324 controls, we genotyped these three polymorphisms and evaluated their association with risk of gastric cancer. We found that the FAS and FASL genotypes and the FAS haplotypes had no significant associations with risk of gastric cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of gastric cancer. The FAS and FASLG polymorphisms may not contribute to risk of gastric cancer in the southern Chinese population.
引用
收藏
页码：559 / 568
页数：10
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