Transcriptional control of brown adipocyte development and physiological function-of mice and men

被引：219
作者：
Seale, Patrick
Kajimura, Shingo
Spiegelman, Bruce M. [1 ]
机构：
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
GENES & DEVELOPMENT | 2009年 / 23卷 / 07期
基金：
日本学术振兴会;
关键词：
PRDM16; FoxC2; brown fat; UCP1; PGC-1; alpha; obesity; MITOCHONDRIAL UNCOUPLING PROTEIN; ADIPOSE-TISSUE; PPAR-GAMMA; STEM-CELLS; COREPRESSOR RIP140; TRANSGENIC MICE; SKELETAL-MUSCLE; GENE-EXPRESSION; RECEPTOR-GAMMA; WHITE FAT;
D O I：
10.1101/gad.1779209
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The last several years have seen an explosion of information relating to the transcriptional control of brown fat cell development. At the same time, new data have emerged that clearly demonstrate that adult humans do indeed have substantial amounts of functioning brown adipose tissue ( BAT). Together, these advances are stimulating a reassessment of the role of brown adipose tissue in human physiology and pathophysiology. These data have also opened up exciting new opportunities for the development of entirely novel classes of therapeutics for metabolic diseases like obesity and type 2 diabetes.
引用
收藏
页码：788 / 797
页数：10
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