Macrophages in Colorectal Cancer Liver Metastases

被引：50

作者：

Cortese, Nina ^{[1
]}

Soldani, Cristiana ^{[2
]}

Franceschini, Barbara ^{[2
]}

Barbagallo, Marialuisa ^{[1
]}

Marchesi, Federica ^{[1
,3
]}

Torzilli, Guido ^{[2
,4
]}

Donadon, Matteo ^{[2
,4
]}

机构：

[1] Humanitas Clin & Res Ctr, Dept Immunol & Inflammat, I-20089 Rozzano, Italy

[2] Humanitas Clin & Res Ctr, Dept Hepatobiliary & Gen Surg, I-20089 Rozzano, Italy

[3] Univ Milan, Dept Biotechnol & Translat Med, I-20090 Segrate, Italy

[4] Humanitas Univ, Dept Biomed Sci, I-20089 Rozzano, Italy

来源：

CANCERS | 2019年 / 11卷 / 05期

关键词：

macrophages; colorectal liver metastases; immune landscape; TUMOR-ASSOCIATED MACROPHAGES; T-CELLS; IMMUNE CELLS; ANGIOGENIC SWITCH; SURVIVAL; INFILTRATION; POLARIZATION; RESECTION; THERAPY; GROWTH;

D O I：

10.3390/cancers11050633

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-associated macrophages (TAMs) provide a nurturing microenvironment for metastasis and are concomitantly key determinants of the efficacy of anticancer strategies. TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liver metastases (CLM) display a high heterogeneity, responsible for a wide array of clinical presentations and responsiveness to treatments. In the era of precision medicine, there is a critical need of reliable prognostic markers to improve patient stratification, and, for their predominance in metastatic tissues, TAMs are emerging as promising candidates.

引用

页数：12

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