A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences

被引：55
作者：
Pandya, Mansi C. [1 ]
Callahan, Sean M. [1 ]
Savchenko, Kyryll G. [1 ]
Stobart, Christopher C. [1 ]
机构：
[1] Butler Univ, Dept Biol Sci, Indianapolis, IN 46208 USA
来源：
PATHOGENS | 2019年 / 8卷 / 02期
关键词：
respiratory syncytial virus; RSV; strain-specific differences; viral evolution; CORYZA AGENT CCA; NF-KAPPA-B; GROUP-A; GLYCOPROTEIN-G; GENOTYPE ON1; SUBGROUP-B; G-PROTEIN; NONSTRUCTURAL PROTEINS; FUSION GLYCOPROTEIN; YOUNG-CHILDREN;
D O I：
10.3390/pathogens8020067
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Respiratory syncytial virus (RSV) is a human respiratory pathogen which remains a leading viral cause of hospitalizations and mortality among infants in their first year of life. Here, we review the biology of RSV, the primary laboratory isolates or strains which have been used to best characterize the virus since its discovery in 1956, and discuss the implications for genetic and functional variations between the established laboratory strains and the recently identified clinical isolates.
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页数：15
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