Lineage II of Southeast Asian/American DENV-2 Is Associated with a Severe Dengue Outbreak in the Peruvian Amazon

被引：52

作者：

Williams, Maya ^{[9
]}

Mayer, Sandra V. ^{[1
,2
]}

Johnson, William L. ^{[10
]}

Chen, Rubing ^{[1
,2
]}

Volkova, Evgeniya ^{[11
]}

Vilcarromero, Stalin ^{[4
]}

Widen, Steven G. ^{[5
]}

Wood, Thomas G. ^{[5
]}

Suarez-Ognio, Luis ^{[12
]}

Long, Kanya C. ^{[13
]}

Hanley, Kathryn A. ^{[3
]}

Morrison, Amy C. ^{[4
,6
]}

Vasilakis, Nikos ^{[7
,8
,14
]}

Halsey, Eric S. ^{[15
]}

机构：

[1] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

[2] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA

[3] New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA

[4] US Naval Med Res Unit 6, Dept Virol, Iquitos, Peru

[5] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA

[6] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA

[7] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA

[8] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 USA

[9] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA

[10] Colorado Sch Publ Hlth, Ft Collins, CO USA

[11] US FDA, Lab Emerging Pathogens, Ctr Biol Evaluat & Res, Div Emerging & Transfus Transmitted Dis, Bethesda, MD 20014 USA

[12] Univ Ciencias Aplicadas, Fac Hlth Sci, Lima, Peru

[13] Andrews Univ, Dept Biol, Berrien Springs, MI 49104 USA

[14] Univ Texas Med Branch, Dept Pathol, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA

[15] US Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2014年 / 91卷 / 03期

关键词：

ADJUSTED LIFE YEARS; HEMORRHAGIC-FEVER; ECONOMIC-IMPACT; VIRUS TYPE-2; FEBRILE ILLNESSES; SHOCK SYNDROME; DECADES; INFECTION; EPIDEMIC; THAILAND;

D O I：

10.4269/ajtmh.13-0600

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years. Whole-genome sequence indicated that DENV-2 from the outbreak belonged to lineage II of the southeast Asian/American genotype and was most closely related to viruses circulating in Brazil during 2007 and 2008, whereas DENV-2 previously circulating in Loreto grouped with lineage I (DENV-2 strains circulating in South America since 1990). One amino acid substitution (NS5 A811V) in the 2010 and 2011 isolates resulted from positive selection. However, the 2010 and 2011 DENV-2 did not replicate to higher titers in monocyte-derived dendritic cells and did not infect or disseminate in a higher proportion of Aedes aegypti than DENV-2 isolates previously circulating in Loreto. These results suggest that factors other than enhanced viral replication played a role in the severity of this outbreak.

引用

页码：611 / 620

页数：10

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