Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus

被引：113

作者：

Parvatkar, Rajesh R. ^{[1
]}

D'Souza, Celina ^{[1
]}

Tripathi, Ashootosh ^{[1
]}

Naik, Chandrakant G. ^{[1
]}

机构：

[1] Natl Inst Oceanog, Bioorgan Chem Lab, CSIR, Panaji 403004, Goa, India

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 01期

关键词：

Aspergillus terreus; Marine natural products; Butenolides; Butyrolactone I; Aspernolides; BUTYROLACTONE-I; METABOLIC PRODUCTS; NATURAL-PRODUCTS; CELL-LINES; DERIVATIVES; INHIBITOR;

D O I：

10.1016/j.phytochem.2008.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone 1, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone 1, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：128 / 132

页数：5

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