The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer

被引:269
作者
Berchtold, Martin W. [1 ]
Villalobo, Antonio [2 ,3 ]
机构
[1] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen N, Denmark
[2] CSIC, Dept Canc Biol, Inst Invest Biomed, E-28029 Madrid, Spain
[3] Univ Autonoma Madrid, E-28029 Madrid, Spain
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2014年 / 1843卷 / 02期
关键词
Calmodulin; Ca2+ binding protein; Cell proliferation; Cancer biology; Apoptosis; Autophagy; DEPENDENT PROTEIN-KINASE; EPIDERMAL-GROWTH-FACTOR; CYCLIC ADP-RIBOSE; ELONGATION FACTOR-2 KINASE; CALCIUM-BOUND CALMODULIN; DELAYED NEURONAL DEATH; BINDING-PROTEIN; FACTOR RECEPTOR; CA2+/CALMODULIN-DEPENDENT KINASE; INTRACELLULAR CA2+;
D O I
10.1016/j.bbamcr.2013.10.021
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Calmodulin (CaM) is a ubiquitous Ca2+ receptor protein mediating a large number of signaling processes in all eulcaryotic cells. CaM plays a central role in regulating a myriad of cellular functions via interaction with multiple target proteins. This review focuses on the action of CaM and CaM-dependent signaling systems in the control of vertebrate cell proliferation, programmed cell death and autophagy. The significance of CaM and interconnected CaM-regulated systems for the physiology of cancer cells including tumor stem cells, and processes required for tumor progression such as growth, tumor-associated angiogenesis and metastasis are highlighted. Furthermore, the potential targeting of CaM-dependent signaling processes for therapeutic use is discussed. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:398 / 435
页数:38
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