'Smart' acid-degradable zinc-releasing silicate glasses

被引：25

作者：

Chen, X. ^{[1
]}

Brauer, D. S. ^{[1
]}

Karpukhina, N. ^{[1
]}

Waite, R. D. ^{[2
]}

Barry, M. ^{[3
]}

McKay, I. J. ^{[4
]}

Hill, R. G. ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, London E1 4NS, England

[2] Barts & London Queen Marys Sch Med & Dent, Blizard Inst, Ctr Immunol & Infect Dis, London E1 2AT, England

[3] Royal London Hosp, Barts & London NHS Trust, Barts & London Orthopaed Ctr, London E1 1BB, England

[4] Queen Mary Univ London, Barts & London Sch Med & Dent, Ctr Adult Oral Hlth, London E1 2AD, England

来源：

MATERIALS LETTERS | 2014年 / 126卷

基金：

美国国家卫生研究院;

关键词：

Coating; Glass; Ion release; Dissolution; Antibacterial; CONTAINING BIOACTIVE GLASSES; CEMENTS; CITRATE; PLAQUE;

D O I：

10.1016/j.matlet.2014.04.009

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Zinc was incorporated in silicate glasses designed as coatings for orthopaedic stainless steel. The glass dissolution behaviour was investigated at physiological (pH 7.35) and acidic pH. Zinc release was low (< 10%) at physiological pH, but increased dramatically under acidic conditions (about 90%) and was proportional to the zinc oxide content in the glasses. Results suggest that zinc oxide enters the silicate network, forming acid-hydrolysable Si-O-Zn bonds. This makes these glasses 'smart' controlled release materials, releasing bactericidal zinc ions under acidic conditions (such as bacterial infections and inflammation) but not under neutral or basic ones. They are therefore great candidates for bactericidal coatings for medical application, potentially preventing implant related infections. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：278 / 280

页数：3

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