Responsive neurostimulation for refractory epilepsy in the pediatric population: A single-center experience

被引：27

作者：

Bercu, Marian Michael ^{[1
,6
]}

Friedman, Daniel ^{[2
]}

Silverberg, Alyson ^{[3
]}

Drees, Cornelia ^{[4
]}

Geller, Eric B. ^{[5
]}

Dugan, Patricia C. ^{[2
]}

Devinsky, Orrin ^{[2
]}

Doyle, Werner H. ^{[2
,3
]}

机构：

[1] NYU Langone Hlth, Dept Neurosurg, Div Pediat Neurosurg, New York, NY USA

[2] NYU Langone Hlth, Comprehens Epilepsy Ctr, New York, NY USA

[3] NYU Langone Hlth, Dept Neurosurg, New York, NY USA

[4] Univ Colorado Denver, Dept Neurol, Epilepsy Sect, Sch Med, Aurora, CO USA

[5] Inst Neurol & Neurosurg St Barnabas, Livingston, NJ USA

[6] Spectrum Hlth, Helen DeVos Childrens Hosp, Div Pediat Neurosurg, Pediat Neurosci Ctr, Grand Rapids, MI 49503 USA

来源：

EPILEPSY & BEHAVIOR | 2020年 / 112卷

关键词：

RNS; Responsive neurostimulation; Epilepsy surgery; Pediatric; ANTERIOR NUCLEUS; STIMULATION; SURGERY; THALAMUS; ADULTS;

D O I：

10.1016/j.yebeh.2020.107389

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Drug-resistant focal epilepsy (DIM) in children can impair cognition and behavior, and lead to premature death. Increased pediatric epilepsy surgery numbers reflect the improvements in seizure control and long-term developmental outcomes. Yet, many children with DRFE are not candidates for surgical resection due to overlap of the seizure network with eloquent cortex or multiple seizure-onset zones, making surgery dangerous or ineffective. In adults, responsive neurostimulation (RNS System) therapy is safe and effective treatment for DRFE with one or two seizure foci, especially when the seizure focus is in eloquent cortex. We present six pediatric patients with DRFE who underwent RNS implantation. Our outcomes demonstrate safety, decreased clinical seizure frequency, as well as improved functional status and quality of life. Changes in the clinical seizure semiology and frequency occurred in conjunction with adjustments to the stimulation parameters, supporting the efficacy of responsive neuromodulation in children. (C) 2020 Elsevier Inc. All rights reserved.

引用

页数：9

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