β-Ketophosphonates as substrates in the Biginelli multicomponent reaction: an efficient and straightforward synthesis of phosphorylated dihydropyrimidinones

被引：17

作者：

Essid, Idris ^{[1
]}

Touil, Soufiane ^{[1
]}

机构：

[1] Univ Carthage, Lab Heteroatom Organ Chem, Dept Chem, Fac Sci Bizerta, Jarzouna 7021, Tunisia

来源：

ARKIVOC | 2013年

关键词：

Multicomponent reactions; Biginelli reaction; dihydropyrimidinones; beta-ketophosphonates; phosphorylated heterocycles; KETO;

D O I：

10.3998/ark.5550190.p007.871

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report an efficient and straightforward multicomponent synthesis of phosphorylated dihydropyrimidinone derivatives, via the p-toluenesulfonic acid promoted Biginelli-type reaction of beta-ketophosphonates, aldehydes and urea. This method offers significant advantages over prior reports, such as efficiency, high yields and mild reaction conditions. Furthermore it is a green protocol avoiding hazardous metal-based catalysts.

引用

页码：98 / 106

页数：9

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