Mutational correlates of response to hypomethylating agent therapy in acute myeloid leukemia

被引:32
作者
Coombs, Catherine C. [1 ]
Sallman, David A. [2 ]
Devlin, Sean M. [3 ]
Dixit, Shweta
Mohanty, Abhinita [5 ]
Knapp, Kristina [4 ]
Al Ali, Najla H. [2 ]
Lancet, Jeffrey E. [2 ]
List, Alan F. [2 ]
Komrokji, Rami S. [2 ]
Padron, Eric [2 ]
Arcila, Maria E. [5 ]
Klimek, Virginia M. [1 ]
van den Brink, Marcel R. M. [6 ]
Tallman, Martin S. [1 ,7 ]
Levine, Ross L. [1 ,4 ]
Rampal, Raajit K. [1 ]
Rapaport, Franck [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, 1275 York Ave, New York, NY 10021 USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL USA
[3] Mem Sloan Kettering Canc Ctr, Dept Biostat & Epidemiol, 1275 York Ave, New York, NY 10021 USA
[4] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA
[5] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA
[6] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA
[7] Weill Cornell Med Coll, New York, NY USA
关键词
OLDER PATIENTS; AZACITIDINE; PHENOTYPE; DNMT3A; IMPACT; IDH2; CARE; AML;
D O I
10.3324/haematol.2016.148999
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E457 / E460
页数:4
相关论文
共 15 条
[1]   Detection of Mutations in Myeloid Malignancies through Paired-Sample Analysis of Microdroplet-PCR Deep Sequencing Data [J].
Cheng, Donavan T. ;
Cheng, Janice ;
Mitchell, Talia N. ;
Syed, Aijazuddin ;
Zehir, Ahmet ;
Mensah, Nana Yaa T. ;
Oultache, Alifya ;
Nafa, Khedoudja ;
Levine, Ross L. ;
Arcila, Maria E. ;
Berger, Michael. F. ;
Hedvat, Cyrus V. .
JOURNAL OF MOLECULAR DIAGNOSTICS, 2014, 16 (05) :504-518
[2]   Lack of association of IDH1, IDH2 and DNMT3A mutations with outcome in older patients with acute myeloid leukemia treated with hypomethylating agents [J].
DiNardo, Courtney D. ;
Patel, Keyur P. ;
Garcia-Manero, Guillermo ;
Luthra, Rajyalakshmi ;
Pierce, Sherry ;
Borthakur, Gautam ;
Jabbour, Elias ;
Kadia, Tapan ;
Pemmaraju, Naveen ;
Konopleva, Marina ;
Faderl, Stefan ;
Cortes, Jorge ;
Kantarjian, Hagop M. ;
Ravandi, Farhad .
LEUKEMIA & LYMPHOMA, 2014, 55 (08) :1925-1929
[3]   International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts [J].
Dombret, Herve ;
Seymour, John F. ;
Butrym, Aleksandra ;
Wierzbowska, Agnieszka ;
Selleslag, Dominik ;
Jang, Jun Ho ;
Kumar, Rajat ;
Cavenagh, James ;
Schuh, Andre C. ;
Candoni, Anna ;
Recher, Christian ;
Sandhu, Irwindeep ;
Bernal del Castillo, Teresa ;
Al-Ali, Haifa Kathrin ;
Martinelli, Giovanni ;
Falantes, Jose ;
Noppeney, Richard ;
Stone, Richard M. ;
Minden, Mark D. ;
McIntyre, Heidi ;
Songer, Steve ;
Lucy, Lela M. ;
Beach, C. L. ;
Doehner, Hartmut .
BLOOD, 2015, 126 (03) :291-299
[4]   Presence of isocitrate dehydrogenase mutations may predict clinical response to hypomethylating agents in patients with acute myeloid leukemia [J].
Emadi, Ashkan ;
Faramand, Rawan ;
Carter-Cooper, Brandon ;
Tolu, Seda ;
Ford, Laurie A. ;
Lapidus, Rena G. ;
Wetzler, Meir ;
Wang, Eunice S. ;
Etemadi, Arash ;
Griffiths, Elizabeth A. .
AMERICAN JOURNAL OF HEMATOLOGY, 2015, 90 (05) :E77-E79
[5]   Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation [J].
Figueroa, Maria E. ;
Abdel-Wahab, Omar ;
Lu, Chao ;
Ward, Patrick S. ;
Patel, Jay ;
Shih, Alan ;
Li, Yushan ;
Bhagwat, Neha ;
Vasanthakumar, Aparna ;
Fernandez, Hugo F. ;
Tallman, Martin S. ;
Sun, Zhuoxin ;
Wolniak, Kristy ;
Peeters, Justine K. ;
Liu, Wei ;
Choe, Sung E. ;
Fantin, Valeria R. ;
Paietta, Elisabeth ;
Lowenberg, Bob ;
Licht, Jonathan D. ;
Godley, Lucy A. ;
Delwel, Ruud ;
Valk, Peter J. M. ;
Thompson, Craig B. ;
Levine, Ross L. ;
Melnick, An .
CANCER CELL, 2010, 18 (06) :553-567
[6]   Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias [J].
Itzykson, R. ;
Kosmider, O. ;
Cluzeau, T. ;
Mansat-De Mas, V. ;
Dreyfus, F. ;
Beyne-Rauzy, O. ;
Quesnel, B. ;
Vey, N. ;
Gelsi-Boyer, V. ;
Raynaud, S. ;
Preudhomme, C. ;
Ades, L. ;
Fenaux, P. ;
Fontenay, M. .
LEUKEMIA, 2011, 25 (07) :1147-1152
[7]  
Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI [10.3322/caac.20006, 10.3322/caac.21254, 10.3322/caac.21332, 10.3322/caac.21551, 10.3322/caac.20073, 10.3322/caac.21387, 10.3322/caac.21654, 10.3322/caac.21601]
[8]   Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia [J].
Kantarjian, Hagop M. ;
Thomas, Xavier G. ;
Dmoszynska, Anna ;
Wierzbowska, Agnieszka ;
Mazur, Grzegorz ;
Mayer, Jiri ;
Gau, Jyh-Pyng ;
Chou, Wen-Chien ;
Buckstein, Rena ;
Cermak, Jaroslav ;
Kuo, Ching-Yuan ;
Oriol, Albert ;
Ravandi, Farhad ;
Faderl, Stefan ;
Delaunay, Jacques ;
Lysak, Daniel ;
Minden, Mark ;
Arthur, Christopher .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (21) :2670-2677
[9]   Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia [J].
Ley, Timothy J. ;
Miller, Christopher ;
Ding, Li ;
Raphael, Benjamin J. ;
Mungall, Andrew J. ;
Robertson, A. Gordon ;
Hoadley, Katherine ;
Triche, Timothy J., Jr. ;
Laird, Peter W. ;
Baty, Jack D. ;
Fulton, Lucinda L. ;
Fulton, Robert ;
Heath, Sharon E. ;
Kalicki-Veizer, Joelle ;
Kandoth, Cyriac ;
Klco, Jeffery M. ;
Koboldt, Daniel C. ;
Kanchi, Krishna-Latha ;
Kulkarni, Shashikant ;
Lamprecht, Tamara L. ;
Larson, David E. ;
Lin, Ling ;
Lu, Charles ;
McLellan, Michael D. ;
McMichael, Joshua F. ;
Payton, Jacqueline ;
Schmidt, Heather ;
Spencer, David H. ;
Tomasson, Michael H. ;
Wallis, John W. ;
Wartman, Lukas D. ;
Watson, Mark A. ;
Welch, John ;
Wendl, Michael C. ;
Ally, Adrian ;
Balasundaram, Miruna ;
Birol, Inanc ;
Butterfield, Yaron ;
Chiu, Readman ;
Chu, Andy ;
Chuah, Eric ;
Chun, Hye-Jung ;
Corbett, Richard ;
Dhalla, Noreen ;
Guin, Ranabir ;
He, An ;
Hirst, Carrie ;
Hirst, Martin ;
Holt, Robert A. ;
Jones, Steven .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (22) :2059-2074
[10]   High-Dose Daunorubicin in Older Patients with Acute Myeloid Leukemia [J].
Lowenberg, Bob ;
Ossenkoppele, Gert J. ;
van Putten, Wim ;
Schouten, Harry C. ;
Graux, Carlos ;
Ferrant, Augustin ;
Sonneveld, Pieter ;
Maertens, Johan ;
Jongen-Lavrencic, Mojca ;
von Lilienfeld-Toal, Marie ;
Biemond, Bart J. ;
Vellenga, Edo ;
Kooy, Marinus van Marwijk ;
Verdonck, Leo F. ;
Beck, Joachim ;
Doehner, Hartmut ;
Gratwohl, Alois ;
Pabst, Thomas ;
Verhoef, Gregor .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (13) :1235-1248