Genetic screens in mice for genome integrity maintenance and cancer predisposition

被引：1

作者：

Balmus, Gabriel ^{[1
,2
]}

McIntyre, Rebecca E. ^{[2
]}

机构：

[1] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England

[2] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2014年 / 24卷

关键词：

DNA-DAMAGE RESPONSE; MOUSE MODEL; CHROMOSOME INSTABILITY; WIDE; ATR; MUTATION; REARRANGEMENTS; TUMORIGENESIS; INSUFFICIENCY; CONSEQUENCES;

D O I：

10.1016/j.gde.2013.10.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genome instability is a feature of nearly all cancers and can be exploited for therapy. In addition, a growing number of genome Maintenance genes have been associated with developmental disorders. Efforts to understand the role of genome instability in these processes will be greatly facilitated by a more comprehensive understanding of their genetic network. We highlight recent genetic screens in model organisms that have assisted in the discovery of novel regulators of genome stability and focus on the contribution of mice as a model organism to understanding the role of genome instability during embryonic development, tumour formation and cancer therapy.

引用

页码：1 / 7

页数：7

共 77 条

[1] A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response [J].

Adamson, Britt ;

Smogorzewska, Agata ;

Sigoillot, Frederic D. ;

King, Randall W. ;

Elledge, Stephen J. .

NATURE CELL BIOLOGY, 2012, 14 (03) :318-+

[2] Genome instability:: a mechanistic view of its causes and consequences [J].

Aguilera, Andres ;

Gomez-Gonzalez, Belen .

NATURE REVIEWS GENETICS, 2008, 9 (03) :204-217

[3] Novel CENPJ mutation causes Seckel syndrome [J].

Al-Dosari, Mohammed S. ;

Shaheen, Ranad ;

Colak, Dilek ;

Alkuraya, Fowzan S. .

JOURNAL OF MEDICAL GENETICS, 2010, 47 (06) :411-414

[4] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[5] A Whole Genome Screen for Minisatellite Stability Genes in Stationary-Phase Yeast Cells [J].

Alver, Bonnie ;

Jauert, Peter A. ;

Brosnan, Laura ;

O'Hehir, Melissa ;

VanderSluis, Benjamin ;

Myers, Chad L. ;

Kirkpatrick, David T. .

G3-GENES GENOMES GENETICS, 2013, 3 (04) :741-756

[6] A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis [J].

Bagley, Bruce N. ;

Keane, Thomas M. ;

Maklakova, Vilena I. ;

Marshall, Jonathon G. ;

Lester, Rachael A. ;

Cancel, Michelle M. ;

Paulsen, Alex R. ;

Bendzick, Laura E. ;

Been, Raha A. ;

Kogan, Scott C. ;

Cormier, Robert T. ;

Kendziorski, Christina ;

Adams, David J. ;

Collier, Lara S. .

PLOS GENETICS, 2012, 8 (11)

[7] Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan [J].

Baker, Darren J. ;

Dawlaty, Meelad M. ;

Wijshake, Tobias ;

Jeganathan, Karthik B. ;

Malureanu, Liviu ;

van Ree, Janine H. ;

Crespo-Diaz, Ruben ;

Reyes, Santiago ;

Seaburg, Lauren ;

Shapiro, Virginia ;

Behfar, Atta ;

Terzic, Andre ;

van de Sluis, Bart ;

van Deursen, Jan M. .

NATURE CELL BIOLOGY, 2013, 15 (01) :96-U208

[8] Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity [J].

Baker, Darren J. ;

Jin, Fang ;

Jeganathan, Karthik B. ;

van Deursen, Jan M. .

CANCER CELL, 2009, 16 (06) :475-486

[9] Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1 [J].

Balmus, Gabriel ;

Zhu, Min ;

Mukherjee, Sucheta ;

Lyndaker, Amy M. ;

Hume, Kelly R. ;

Lee, Jaesung ;

Riccio, Mark L. ;

Reeves, Anthony P. ;

Sutter, Nathan B. ;

Noden, Drew M. ;

Peters, Rachel M. ;

Weiss, Robert S. .

HUMAN MOLECULAR GENETICS, 2012, 21 (15) :3408-3420

[10]

Bhattacharya N., 2012, ANN SURG ONCOL

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