Transcription Factor Activating Protein-2β (TFAP-2β) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples

被引：5

作者：

Nilsson, Kent W. ^{[1
]}

Sonnby, Karin ^{[1
]}

Nordquist, Niklas ^{[2
]}

Comasco, Erika ^{[2
]}

Leppert, Jerzy ^{[1
]}

Oreland, Lars ^{[2
]}

Sjoberg, Rickard L. ^{[3
]}

机构：

[1] Uppsala Univ, Vastmanland Cty Hosp, Clin Res Ctr, S-72189 Vasteras, Sweden

[2] Uppsala Univ, Dept Neurosci, S-75124 Uppsala, Sweden

[3] Univ Hosp Umea, Dept Neurosurg, S-90185 Umea, Sweden

来源：

EUROPEAN CHILD & ADOLESCENT PSYCHIATRY | 2014年 / 23卷 / 04期

基金：

瑞典研究理事会;

关键词：

ADHD; Adolescents; Comorbidity; Depression; Gene-environment interaction; Transcription factor AP-2 beta; SEROTONIN TRANSPORTER GENE; MAO-A GENE; TRANSCRIPTION FACTOR; MAJOR DEPRESSION; FAMILY FUNCTION; ADULT ADHD; ADOLESCENT; GENDER; SEX; ASSOCIATION;

D O I：

10.1007/s00787-013-0450-6

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

The Transcription Factor Activating Protein-2 beta (TFAP-2 beta) gene has been shown to influence monoaminergic neurotransmission, and several genes important for monoaminergic function have binding sites for TFAP-2 beta. Familial studies of attention deficit hyperactivity disorder (ADHD) suggest a hereditary-determined subtype of ADHD with comorbid depression. We examined a functional variation of the TFAP-2 beta gene in the context of co-occurring symptoms of ADHD and depression in two independent population-based samples of adolescents (Group A, n = 175 and Group B, n = 1,506) from Sweden. Results indicated 6.1 to 7.8 % of adolescents screened positively for ADHD and depression symptoms. Symptoms of depression were more common among girls who screened positively for ADHD and did not carry the nine-repeat allele of the TFAP-2 beta intron 1 Variable Number Tandem Repeat (VNTR) polymorphism. The presence of the nine-repeat variant of the TFAP-2 beta intron 1 VNTR appears to protect girls with ADHD symptoms from the co-expression of symptoms of depression.

引用

页码：207 / 217

页数：11