Rice plantation is one of the sectors that severely affected by drought stress worldwide and caused high loss of rice production. Latest, approximately 1164 ha rice plantation was affected due to water scarcity in Malaysia and reduced rice production. This study suggest that treatment by using liquid formulation containing macronutrient and plant growth regulators as one of the strategies to alleviate drought stress in plant growth and development. Hence, this study aimed to assess the synergistic effect of KCl, thiourea (TU), GA(3) and SA for the germination and early growth enhancement of drought-stressed rice cv. MR220. MR220 seeds were stressed in -1.2 MPa PEG 6000 solution and germinated in petri dishes containing KCl, TU, GA(3) and SA separately for ten days. Results showed that, 1.0 mM of KCl, 2.0 mM of TU, 0.06 mM of GA(3) and 1.0 mM of SA were the ideal concentration that enhance the germination and early seedling growth of drought-stressed MR220. Next, the ideal concentrations were combined and the result showed that the best combination treatments for drought-stressed MR220 were 1.0 mM KCl +0.06 mM GA(3), 0.06 mM GA(3) + 1.0 mM SA and 1.0 mM KCl +2.0 mM TU + 0.06 mM GA(3). These combination treatments significantly increased the germination and seedling growth performance of drought-stressed MR220. The combination treatment of 1.0 mM KCl +2.0 mM TU + 0.06 mM of GA(3) showed the most effective in improving germination and seedling growth performance of drought-stressed MR220.