Facile synthesis of three bidesmosidic oleanolic acid saponins with strong inhibitory activity on pancreatic lipase

被引：31

作者：

Guo, Tiantian ^{[1
]}

Liu, Qingchao ^{[1
]}

Wang, Peng ^{[1
]}

Zhang, Lei ^{[1
]}

Zhang, Wei ^{[1
]}

Li, Yingxia ^{[1
]}

机构：

[1] Ocean Univ China, Key Lab Marine Drugs, Minist Educ China, Sch Med & Pharm, Qingdao 266003, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2009年 / 344卷 / 10期

关键词：

Scabiosaponins; Bidesmosidic oleanolic acid saponins; One-pot sequential glycosylation; Trichloroacetimidates; p-Toluenethioglycosides; POT SEQUENTIAL GLYCOSYLATION; TRITERPENOID SAPONINS; PRACTICAL SYNTHESIS; DIOSGENYL SAPONINS; HIGHLY EFFICIENT; DERIVATIVES; GLYCOSIDES; BEARING; TRICHLOROACETIMIDATE; CYTOTOXICITY;

D O I：

10.1016/j.carres.2009.04.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first synthesis of scabiosaponins E (1), F (2), and G (3), three new oleanolic acid saponins with strong inhibitory activity on pancreatic lipase isolated from the Chinese traditional medicinal herb Scabiosa tschiliensis, was efficiently achieved in an one-pot strategy under the combined use of glycosyl trichloro-acetimidates and p-toluene 1-thioglycosides (STol) as donors. (C) 2009 Published by Elsevier Ltd.

引用

页码：1167 / 1174

页数：8

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