Phase Separation and the Centrosome: A Fait Accompli?

被引:52
作者
Raff, Jordan W. [1 ]
机构
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England
基金
英国惠康基金;
关键词
HAMSTER OVARY CELLS; PERICENTRIN-LIKE-PROTEIN; GAMMA-TUBULIN; CAENORHABDITIS-ELEGANS; MITOTIC CENTROSOME; MICROTUBULE NUCLEATION; ASSEMBLY PATHWAY; CENTRIOLE CYCLE; CNN SCAFFOLD; AURORA-A;
D O I
10.1016/j.tcb.2019.04.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
There is currently intense interest in the idea that many membraneless organelles might assemble through phase separation of their constituent molecules into biomolecular 'condensates' that have liquid-like properties. This idea is intuitively appealing, especially for complex organelles such as centrosomes, where a liquid-like structure would allow the many constituent molecules to diffuse and interact with one another efficiently. I discuss here recent studies that either support the concept of a liquid-like centrosome or suggest that centrosomes are assembled upon a more solid, stable scaffold. I suggest that it may be difficult to distinguish between these possibilities. I argue that the concept of biomolecular condensates is an important advance in cell biology, with potentially wide-ranging implications, but it seems premature to conclude that centrosomes, and perhaps other membraneless organelles, are necessarily best described as liquid-like phase-separated condensates.
引用
收藏
页码:612 / 622
页数:11
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